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Background <p>Asthma is a common chronic disease responsible for a considerable disease burden in China and around the world. Despite its burden, there is substantial unmet need for asthma care, including screening, diagnosis, treatment, and management. Symptom-based screening for asthma could support identification of undiagnosed asthma patients, as well as reference to higher-level hospitals for formal diagnoses and treatment. This study focuses on identifying suspected asthma patients and encouraging them to seek formal diagnoses and treatment. This approach aligns with the novel concept of population medicine, which aims to maximize overall population health rather than focusing on individual patients within the health system.</p> Methods <p>We are conducting a two-arm population-based stratified clustered randomized controlled trial (cRCT) to evaluate the effectiveness of a population medicine multimorbidity intervention package. The intervention integrates community screening, chronic disease management, patient education, digital follow-up, and team-based care. The trial is being implemented in Xishui County, Guizhou Province, a mountainous low-resource county in Southwestern China, covering 26 townships and more than 300,000 permanent residents. We considered each of the 26 townships in Xishui County as a cluster and stratified them into large and small townships based on population size. Townships with an above-average population were designated as “large,” and those with a below-average population were designated as “small.” We randomized the same number of residents in each township stratum (large and small) to undergo the European Community Respiratory Health Survey (ECRHS) for identifying suspected asthma patients. Individuals identified as suspected asthma patients were considered study participants and subsequently enrolled in the intervention or control arm. All participants in the intervention arm are followed for one year, with one telephone follow-up at month three and in-person follow-ups at months six and 12, while participants in the control arm are followed only at baseline and 12&#xa0;months. Primary outcomes include the number of chronic conditions controlled, whether the participant received lung function testing, and Asthma Control Test (ACT) score. In addition, we are evaluating 42 secondary outcomes covering physiological and functional indicators such as lung function, health-related quality of life, mental health, behavioral risk factors, healthcare utilization, productivity loss, knowledge of asthma and chronic obstructive pulmonary disease (COPD), and care cascade indicators for asthma and other chronic diseases.</p> Discussion <p>This cRCT has been featured as an important case study in the <i>Lancet</i> Commission on Investing in Health report to evaluate the effectiveness of the integrated intervention package on priority conditions. The trial was designed under population medicine principles, with an aim providing holistic care and enhancing the overall health status of suspected asthma patients. The results of the trial will inform the next generation of multimorbidity management and population medicine practices among global health authorities and practitioners.</p> Trial registration <p>ClinicalTrials.gov Identifier: NCT06457009. Registered on June 7, 2024.</p>

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Impact of the POPulation Medicine Multimorbidity Intervention in Xishui County (POPMIX) on suspected asthma patients: protocol for the POPMIX-Asthma cluster-randomized controlled trial

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  • 发表日期：

    2026年4月11日

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  • Ke Huang,
  • Xunliang Tong,
  • Xingyao Tang,
  • Qiande Lai,
  • Yuhao Liu,
  • Shiyu Zhang,
  • Zhoutao Zheng,
  • Wenjin Chen,
  • Zhong Cao,
  • Lei Tang,
  • Jinghan Zhao,
  • Liu He,
  • Lirui Jiao,
  • Yingping Wang,
  • Tianying Zhao,
  • Yingchi Luo,
  • Xiangqin Lyu,
  • Qiushi Chen,
  • Sebastian Vollmer,
  • Pascal Geldsetzer,
  • Dean Jamison,
  • Till Bärnighausen,
  • Simiao Chen,
  • Chen Wang,
  • Ting Yang,
  • Chun Zhang,
  • Yuzhu Ye,
  • Mingqiang Hou,
  • Shengbo Liao,
  • Yuan Zhou,
  • Dong Liu,
  • Chentao Zhong,
  • Yushuang Zhao,
  • Hongxia Mu,
  • Min Liu,
  • Qiong Lyu,
  • Zhengyu Zhang,
  • Weiwei Li,
  • Jian Wang,
  • Tiansheng Lan,
  • Tingyu Liu,
  • Xin Zhou,
  • Bie Yu,
  • Xianping Wang,
  • Yansong Luo,
  • Wenwu Jiang,
  • Wen Zhang,
  • Dongmei Wu,
  • Qingping Luo,
  • Dajun Rao,
  • Cunkun Yang,
  • Feng Zhao,
  • Qin Wang,
  • Linlin Zhang,
  • Can Li,
  • Min Chen,
  • Yufeng Huang,
  • Guanghai Jian,
  • Li Wang,
  • Yunjiang Zheng,
  • Jianghong Linghu,
  • Li Zhong,
  • Xiaoling Ma,
  • Bin Gui,
  • Yan Cheng,
  • Yu Yang,
  • Jing Yan,
  • Xixi Liao,
  • Mingguo Xu,
  • Zhijun Zhao,
  • Qian Han,
  • Panyan Wu,
  • Dandan Tang,
  • Qingqing Wang,
  • Li Feng,
  • Lilan Wang,
  • Lei Si,
  • Peng Zeng,
  • Jianxiu Tian,
  • Weili Fan,
  • Xin Luo,
  • Sumei Feng,
  • Rong Ding,
  • Huadan Yi,
  • Fengxue Lyu,
  • Ludan Yuan,
  • Yuan Liu,
  • Xueshuang Wang,
  • Aihong Duan,
  • Yang Zhao,
  • Yuping Luo,
  • Yicheng Li,
  • Anchun Liang,
  • Chengmei Li,
  • Hu Tang,
  • Anfeng Liu,
  • Xu Wang,
  • Yi Zhong,
  • Wen Zheng,
  • Benwei Zhao,
  • Qianmei Zhang,
  • Xiaojing Tu,
  • Huanhuan Lu,
  • Xiumei Zhao,
  • Yan Chen,
  • Xuemei Yuan,
  • Yanhong Mu,
  • Yao Zhao,
  • Juan Zhang,
  • Qinhui Li,
  • Fuhui Wang,
  • Xiaomin Mu,
  • Yan Hu,
  • Liuyang Chen,
  • Gang Lei,
  • Zhufei Hu,
  • Yan Luo,
  • Shunxia Zhou,
  • Ting Pan,
  • Yuanyin Zhou,
  • Xiaoqin Ren,
  • Yaling Zhou,
  • Jing Zeng,
  • Keping Hu,
  • Xiaoyu Liu,
  • Deguo Yang,
  • Qiong Wan,
  • Cai Zhang,
  • Heng He,
  • Chengping Wang,
  • Yuanzhong Wang,
  • Shuyin Wang,
  • Xuhong Lei,
  • Yushen Yuan,
  • Tailiang Luo,
  • Dazhou Zhu,
  • Anrong Luo,
  • Xianmei Hu,
  • Ya Zhang,
  • Ling Yuan,
  • Senlin Luo,
  • Weili Ma,
  • Yonghua Cao,
  • Yunpeng Cao,
  • Taojin Chen,
  • Wen Chen,
  • Zhiqun Chen,
  • Zhongyi Chen,
  • Huagang Cheng,
  • Xianpan Feng,
  • Taimei Gao,
  • Lizhu Jian,
  • Renxian Jiang,
  • Shengmei Kang,
  • Hang Lei,
  • Shanshan Liu,
  • Ruxun Lu,
  • Xiaojiao Luo,
  • Dongshun Lyu,
  • Guanghong Meng,
  • Jianping Mu,
  • Xuerou Mu,
  • Hongxia Qian,
  • Huimin Ren,
  • Juan Wang,
  • Li Wang,
  • Loutao Wang,
  • Qin Wang,
  • Wei Wang,
  • Ya Wang,
  • Yan Wang,
  • Dongjie Wu,
  • Xiaoxia Xu,
  • Jing Yang,
  • Qian Yu,
  • Dan Yuan,
  • Yanlu Yuan,
  • Yu Yuan,
  • Hongying Yue,
  • Yuanmin Yue,
  • Li Zhang,
  • Zhizhong Zhang,
  • Jiaqin Zhao,
  • Yuanxin Zhao,
  • Yue Zhong,
  • Lejie Zhou,
  • Lufang Yang,
  • Xue Chen,
  • Lihui Ren,
  • Guixiang Gong,
  • Ping Shi,
  • Jiangshun Tan,
  • Zhonghang Yu,
  • Lijun Mu,
  • Meilin Chen,
  • Su Yu,
  • Lin Li,
  • Xianbi Mu,
  • Jianxia Wu,
  • Mei Zhao,
  • Jiangmei Chen,
  • Jing Huang,
  • Yanfang Li,
  • Huayan Yang,
  • Jiaheng Yang,
  • Xingqi Yuan,
  • Yunhao Zhou,
  • Mengting Ye,
  • Junlin Zhang,
  • Taijun Luo,
  • Shuai Wang,
  • Ju Hu,
  • Gang Yuan,
  • Shili Mu,
  • Zhongxiang Yuan,
  • Huili He,
  • Jiali Li,
  • Chunlan Liu,
  • Kailiang Cheng,
  • Quan Liu,
  • Huade Yang,
  • Shaojun Zhang,
  • Bo Chen,
  • Guishan Ying,
  • Xumei Zhao,
  • Zhi He,
  • Gan Feng,
  • Huanhuan Guo,
  • Hongling Yuan,
  • Fuyou Yuan,
  • Wei Wang,
  • Lang Chen,
  • Liping Zhao,
  • Jiajun Ning,
  • Jie Feng,
  • Yuxian Chen,
  • Jin Chen,
  • Jing Qi,
  • Yuanting Li,
  • Lingli Zhao,
  • Guo Wang,
  • Ziyi Wang,
  • Huaishu Zhong,
  • Jie Wang,
  • Gang Chen,
  • Xueqin Mu,
  • Yuanfeng Gong,
  • Xinan Lu,
  • Zhengli Chen,
  • Tianwei Chen,
  • Xiaoping Chen,
  • Runqin Mu,
  • Xiaoyi Deng,
  • Yu Duan,
  • Xiujuan Dong,
  • Wangyong Yan,
  • Jiayong Rao,
  • Mingfang Wang,
  • Xiangcai Chen,
  • Zhongquan Wang,
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  • Jianghua Luo,
  • Kaijie Huang,
  • Ye Chen,
  • Jin’e Li,
  • Li Huang,
  • Ju Chen,
  • Hao Huang,
  • Qingqun Long,
  • Yan Chen,
  • Ling Jiang,
  • Man Ding,
  • Xiaolin Yu,
  • Tongjie Wei,
  • Zhengqin Liu,
  • Kaifu Si,
  • Yuxian Mu,
  • Yan Huang,
  • Qian Yang,
  • Tao Xu,
  • Xiaorong Yuan,
  • Cailun Zhao,
  • Minli Chen,
  • Rongfang Luo,
  • Ling Chen,
  • Ying Zhang,
  • Guiwei Yuan,
  • Qianyi Shui,
  • Yong Wu,
  • Qian Huang,
  • Changli Wu,
  • Nan Zhang,
  • Chaojiang Wu,
  • Defei Chen,
  • Wu Xu,
  • Linhui He,
  • Wanlun Zhang,
  • Jinsong Chen,
  • Jin Yuan,
  • Rujun Li,
  • Minghe Wang,
  • Chunmei Zhang,
  • Yueshan Wang,
  • Lang Liao,
  • Anqian Feng,
  • Dengyang Wang,
  • Zelin Deng,
  • Hupiao Yang,
  • Kaimeng You,
  • Lijuan Deng,
  • Qiong Huang,
  • Xiaoqing Zhang,
  • Zhengqian Zhu,
  • Xiaoyan Liao,
  • Yongbo Song,
  • Yushui Yuan,
  • Qinghong Cai,
  • Lu Liu,
  • Hong Yu,
  • Xue Luo,
  • Xiaoshan Huang,
  • Qin Hu,
  • Dian Yuan,
  • Zengye Zhao,
  • Jiemin Zeng,
  • Zhaoyan Huang,
  • Peng Luo,
  • Taibo Luo,
  • Wenwu Wu,
  • Guangni Liu,
  • Gengning Zhang,
  • Mingyuan Ren,
  • Mei Yang,
  • Zhongjin Wang,
  • Rongping Yuan,
  • Yunfeng Yuan,
  • Anquan Yuan,
  • Yunqiang Chen,
  • Hongxian Liu,
  • Xingyu He,
  • Tongxiang Zhang,
  • Mingkai Xu,
  • Minqing Hu,
  • Chunyi Qian,
  • Yunfen Zhang,
  • Yueguang Lei,
  • Jun Wang,
  • Xiaoju Yuan,
  • Changxian Yang,
  • Ai Xiang,
  • Minjing Zhao,
  • Xiaomei Ren,
  • Guimei Li,
  • Huiying Ren,
  • Ju Teng,
  • Yu Chen,
  • Jing Yuan,
  • Shunfeng Mu,
  • Xiangyu Zhang,
  • Ye Li,
  • Yuwei Sun,
  • Shangjing Wang,
  • Fangping He,
  • Guoxiang Wang,
  • Wei Cai,
  • Weijiang Tian,
  • Tingfen Cai,
  • Zhao Chen,
  • Dakai Mu,
  • Yufu Mu,
  • Cai Cheng,
  • Xiaofang Pan,
  • Fang Wang,
  • Mingqian Zhao,
  • Qijun Liu,
  • Bangqi Yang,
  • Ye Yu,
  • Ting Min,
  • Xiaoya Wang,
  • Jun Li,
  • Yang Zhang,
  • Yan Wang,
  • Lihong Zhao,
  • Zhihua Luo,
  • Hao Yuan,
  • Huihua Ruan,
  • Jian Wu,
  • Chengfen Wang,
  • Dezhi Zhang,
  • Yunfang Zhang,
  • Weining Ao,
  • Pan Zhao,
  • Yunxia Liang,
  • Yicheng Zhao,
  • Xiaosong Mu,
  • Lyufang Luo,
  • Ziyi Zhang,
  • Wei Huang,
  • Jun Cao,
  • Huan Li,
  • Jun Liu,
  • Liye Yuan,
  • Na Zhao,
  • Ju Wang,
  • Qiuyan Duan,
  • Weizhong Chen,
  • Lirong Zhao,
  • Jiangbo Wu,
  • Liqin Deng,
  • Kunyu Wang,
  • Zhengguo Yan,
  • Chaolian Wang,
  • Can Liu,
  • Quan Cao,
  • Gang Ma,
  • Youyong Lu,
  • Yuan Zhang,
  • Kaijing Xiang,
  • Yixiang Wang,
  • Xingye Zhu,
  • Jiamei Wang,
  • Demin Hu,
  • Dongmin Li,
  • Peng Chen,
  • Chao Tian,
  • Lu Wang,
  • Mei Wang,
  • Lulu Xiao,
  • Lingling Yu,
  • Min Wei,
  • Chengcheng Yang,
  • Limei Zhang,
  • Rong Zhao,
  • Chongguang Zhong,
  • Yan Xiao,
  • Jian Luo,
  • Hongfa Chen,
  • Pengju Dai,
  • Jin Liu,
  • Yingtao Luo,
  • Guangjie Ma,
  • Shiyou Mu,
  • Zhengli Rao,
  • Deqin Wen,
  • Guowang Wu,
  • Yong Hu,
  • Xiaorong Shi,
  • Shaofen Huang,
  • Ya Chen,
  • Wenmao Zhang,
  • Min Chen,
  • Xin Luo,
  • Hongqiong Ruan,
  • Liming Liu,
  • Lihui Fan,
  • Xiaoyan Zou,
  • Huizhi He,
  • Xinggao Yang,
  • Linfei Wang,
  • Hong Wang,
  • Wenxiang Li,
  • Jialian Wu,
  • Jinyong Yang,
  • Jianying Wu,
  • Guangliang Liu,
  • Xiaolin Xiong,
  • Gang Yang,
  • Ping Feng,
  • Cheng Luo,
  • Qiwei Zhang,
  • Qihui Yang,
  • Taoshan Ni,
  • Rensong Tian,
  • Li Zhang,
  • Yuanmei Zhang,
  • Hui Bi,
  • Bijue Huang,
  • Yu Yan,
  • Shan Chen,
  • Xinghui Chen,
  • Jiangfei Wang,
  • Guanglun Zou,
  • Junting Liu,
  • Rongjiang Zhao,
  • Li Yuan,
  • Ruyin Yuan,
  • Jianbing Li,
  • Aiping Wang,
  • Daijie Wang,
  • Mei Yang,
  • Kaiyan Si,
  • Peng Wang,
  • Yan Linghu,
  • Tuye Yuan,
  • Zhiyuan Yuan,
  • Weiwei Qian,
  • Daimei Wang,
  • Rongqin Ren,
  • Dong Dai,
  • Qianhua Deng,
  • Yan Xu,
  • Jiali Zhang,
  • Qingyan Bai,
  • Yingwen Zhang,
  • Xingke Wang,
  • Qiang Liu,
  • Liyuan Feng,
  • Fancha Wang,
  • Shiwen Wang,
  • Xiangguang Liu,
  • Runping Liu,
  • Xiaoying Wang,
  • Daizhi Wang,
  • Huihai Cao,
  • Jiang Yuan,
  • Qinhui Cao,
  • Min Luo,
  • Hao Hou,
  • Lu Kong,
  • Zhu Ren,
  • Yu Zhou,
  • Xiaoyan Yuan,
  • Hong Liu,
  • Shixian Gong,
  • Yonghong Zhao,
  • Rusheng Wang,
  • Ji Chen,
  • Fuping Bai,
  • Yang Zhou,
  • Wenbi Chen,
  • Yu Sun,
  • Qunying Xu,
  • Gang Zheng,
  • Yong Wang,
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  • Ling Zhong,
  • Ji Ren,
  • Qiling Zhu,
  • Zheng Yang,
  • Yongsong Chen,
  • Zhonghui Huang,
  • Xiaojiang Zhang,
  • Junyan Yu,
  • Panting Yu,
  • Qun Wang,
  • Qimei Yu,
  • Hao Zhou,
  • Yuanmei Lu,
  • Yiyu Wang,
  • Min Huang,
  • Feng Wu,
  • Jiangyu Yuan,
  • Guangjun Xiong,
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  • Hong Zhou,
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  • Xiaoli Ye,
  • Qingli Luo,
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  • Fuxiu Yang,
  • Minqin Hu,
  • Tingting Yuan,
  • Song Zhou,
  • Lin Yuan,
  • Mingjian Yuan,
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  • Hongming Zhao,
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  • Hua Xiong,
  • Qiyong Yuan,
  • Qin Yuan,
  • Xingqin Zhao,
  • Qifu Luo,
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  • Tulin Yuan,
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  • Chun Luo,
  • Dehong Wang,
  • Rongwei Zhang,
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  • Zhong’en Wang,
  • Deping Yuan,
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  • Huahua Li,
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  • Junjun Xia,
  • Tingxian Mao,
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  • Chengshang Ao,
  • Xu Zhong,
  • Yang Liu,
  • Langsha Chen,
  • Huan Luo,
  • Qingxia Wang,
  • Chen Chen,
  • Wenqiang Wu,
  • Yumei Wu,
  • Limei Feng,
  • Caixian Lei,
  • Kai Li,
  • Youqun Chen,
  • Lulu Zhao,
  • Han Ren,
  • Juhang Yang,
  • Shanshan Luo,
  • Xiaoyi Zhang,
  • Huiqin Yuan,
  • Li Chen,
  • Guishuang Liu,
  • Jiakuan Ren,
  • Dongqiao Jiang,
  • Yi Yuan,
  • Dengmin Ren,
  • Xiaojiang Mu,
  • Xue Yang,
  • Wuyao He,
  • Wanyi Hu,
  • Piaopiao Huang,
  • Guijiang Li,
  • Jinman Li,
  • Suosuo Li,
  • Yiling Lu,
  • Yuqi Lu,
  • Huan Luo,
  • Qingqing Luo,
  • Wenqin Mu,
  • Daolin Qin,
  • Jinlan Quan,
  • Yingying Tang,
  • Junbao Wang,
  • Lingling Wang,
  • Rui Xu,
  • Chenxi Yang,
  • Dengqin Yang,
  • Liqin Yang,
  • Qingting Zhang,
  • Lei Zhao,
  • Lin Zhao,
  • Jingmei Zhou,
  • Lijuan Zuo,
  • Xiaoning Xia,
  • Yujia Xie,
  • Hangyu Chen,
  • Li Yang,
  • Yu Zhao,
  • Sisi Li,
  • Juan Pan,
  • Ju Yang,
  • Minjia Zhao,
  • Meiyuan Zhou,
  • Guimei Hu,
  • Chunqin Huang,
  • Haiyan Long,
  • Zeyuan Luo,
  • Donghua Pan,
  • Xuelang Ying,
  • Yanyan Zhang,
  • Yuting Zhang,
  • Hong Zhao,
  • Yunli Zhou,
  • Bijin Zhu,
  • Kang Chen,
  • Kaidi Ding,
  • Jiacheng Dong,
  • Tai Fu,
  • Qin Li,
  • Zaijing Liu,
  • Siqi Huang,
  • Lingli Ou,
  • Zhuoting Tan,
  • Yan Tang,
  • Qingzhong Wu,
  • Xinyi Xu,
  • Bingyang Xu,
  • Yulin Zhang,
  • Shuangshuang Zhou,
  • Zena Zhu,
  • Jiancao Zuo,
  • Guangxianfeng Chen,
  • Jiahui Luo,
  • Zhiqi Duan,
  • Shangrong Gu,
  • Binyao Ou,
  • Xingtai Zhao,
  • Yanran He,
  • Xingli Liao,
  • Shunxin Shi,
  • Cheng Wang,
  • Jiayu Wang,
  • Rongmei Wang,
  • Ruirui Zhang,
  • Yuhan Zhou,
  • Serena Luo,
  • Jiwei Jin,
  • Xiaoqi Shi,
  • Ziqianqian Yang,
  • Xiaoxue An,
  • Jiwei Jin,
  • Mingli Huang,
  • Yinghua Mu,
  • Xiaozheng Wang,
  • Songlin Zhang,
  • Xue Zhou,
  • Ruirui Ao,
  • Shaohuan Bao,
  • Yating Jiang,
  • Yijun Liu,
  • Zhirui Nie,
  • Dingyuan Rao,
  • Jiangqin Wan,
  • Xue Wang,
  • Die Wei,
  • Lijin Xie,
  • Jianan Xu,
  • Xuerong Zhang,
  • Die Deng,
  • Jingyu Fu,
  • Shunli Guo,
  • Binhan He,
  • Sitong Liu,
  • Lin Liu,
  • Linqu Qin,
  • Teng Tian,
  • Kehao Wang,
  • Qirui Wu,
  • Laitian Ye,
  • Xiao Zhang,
  • Tiantian Zhou,
  • Sitong Zhou,
  • Jiajia Liu,
  • Huali Yin,
  • Yue Luo,
  • Jianxiu Bai,
  • Yuchan Li,
  • Xinglian Zhang,
  • Shenghui Zhu,
  • Xue Chen,
  • Dan Jiang,
  • Xiaoqin Yang,
  • Changnan Zhao,
  • Fangjing Geng,
  • Jia Li,
  • Jie Wang,
  • Wenfan Hu,
  • Xingling Li,
  • Yumei Lu,
  • Zhuying Long,
  • Junxue Qian,
  • Guoxian Shi,
  • Ruoxi Wang,
  • Guangjian Wu,
  • Guangyan Zhang,
  • Rongrong Zhou,
  • Hongyu Hu,
  • Zhaoyi Ren,
  • Lingxuan Shi,
  • Meng Zeng,
  • Shengsheng Li,
  • Ying Qin,
  • Yi Zhou,
  • Tianyu Liu,
  • Jia He,
  • Jinan Li,
  • Mingyuan Mao,
  • Jiayi Wang,
  • Ronghui Ma,
  • Bin Li

摘要

Background

Asthma is a common chronic disease responsible for a considerable disease burden in China and around the world. Despite its burden, there is substantial unmet need for asthma care, including screening, diagnosis, treatment, and management. Symptom-based screening for asthma could support identification of undiagnosed asthma patients, as well as reference to higher-level hospitals for formal diagnoses and treatment. This study focuses on identifying suspected asthma patients and encouraging them to seek formal diagnoses and treatment. This approach aligns with the novel concept of population medicine, which aims to maximize overall population health rather than focusing on individual patients within the health system.

Methods

We are conducting a two-arm population-based stratified clustered randomized controlled trial (cRCT) to evaluate the effectiveness of a population medicine multimorbidity intervention package. The intervention integrates community screening, chronic disease management, patient education, digital follow-up, and team-based care. The trial is being implemented in Xishui County, Guizhou Province, a mountainous low-resource county in Southwestern China, covering 26 townships and more than 300,000 permanent residents. We considered each of the 26 townships in Xishui County as a cluster and stratified them into large and small townships based on population size. Townships with an above-average population were designated as “large,” and those with a below-average population were designated as “small.” We randomized the same number of residents in each township stratum (large and small) to undergo the European Community Respiratory Health Survey (ECRHS) for identifying suspected asthma patients. Individuals identified as suspected asthma patients were considered study participants and subsequently enrolled in the intervention or control arm. All participants in the intervention arm are followed for one year, with one telephone follow-up at month three and in-person follow-ups at months six and 12, while participants in the control arm are followed only at baseline and 12 months. Primary outcomes include the number of chronic conditions controlled, whether the participant received lung function testing, and Asthma Control Test (ACT) score. In addition, we are evaluating 42 secondary outcomes covering physiological and functional indicators such as lung function, health-related quality of life, mental health, behavioral risk factors, healthcare utilization, productivity loss, knowledge of asthma and chronic obstructive pulmonary disease (COPD), and care cascade indicators for asthma and other chronic diseases.

Discussion

This cRCT has been featured as an important case study in the Lancet Commission on Investing in Health report to evaluate the effectiveness of the integrated intervention package on priority conditions. The trial was designed under population medicine principles, with an aim providing holistic care and enhancing the overall health status of suspected asthma patients. The results of the trial will inform the next generation of multimorbidity management and population medicine practices among global health authorities and practitioners.

Trial registration

ClinicalTrials.gov Identifier: NCT06457009. Registered on June 7, 2024.