Scholarlink

Background <p>Pterygium is a wing-shaped fibrovascular growth over the cornea that may require surgical removal due to recurrence and cosmetic concerns. This randomized controlled trial compares the recurrence rate of conjunctival-limbal autograft (CLAu) with a modified mini-simple limbal epithelial transplant (mini-SLET) technique.</p> Methods <p>68 patients will be randomly assigned to two equally sized groups via simple randomization. Group I will undergo a pterygium excision with CLAu, while Group II will undergo a pterygium excision using a mini-SLET. Allocation concealment will be ensured using sealed envelopes, and procedures will be performed by two surgeons. Patients will be followed postoperatively at regular intervals for up to 12&#xa0;months.</p> Discussion <p>This study builds on previous research by modifying the mini-SLET technique to enhance corneal stem cell viability and reduce recurrence. By refining this method, we aim to offer patients a more effective and minimally invasive alternative to the gold-standard procedure.</p> Trial registration <p>ClinicalTrials.gov, NCT06402643. Registered on April 15, 2024.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mini-simple limbal epithelial transplantation and conjunctival-limbal autograft for the treatment of primary pterygium: Study protocol for a randomized controlled trial

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月31日

查看全文
  • Guillermo Raul Vera-Duarte,
  • Gustavo Ortiz-Morales,
  • Carlos Adolfo Müller-Morales,
  • Alejandro Navas,
  • Arturo Ramirez-Miranda,
  • Enrique O. Graue-Hernandez,
  • Nicolás Kahuam-López

摘要

Background

Pterygium is a wing-shaped fibrovascular growth over the cornea that may require surgical removal due to recurrence and cosmetic concerns. This randomized controlled trial compares the recurrence rate of conjunctival-limbal autograft (CLAu) with a modified mini-simple limbal epithelial transplant (mini-SLET) technique.

Methods

68 patients will be randomly assigned to two equally sized groups via simple randomization. Group I will undergo a pterygium excision with CLAu, while Group II will undergo a pterygium excision using a mini-SLET. Allocation concealment will be ensured using sealed envelopes, and procedures will be performed by two surgeons. Patients will be followed postoperatively at regular intervals for up to 12 months.

Discussion

This study builds on previous research by modifying the mini-SLET technique to enhance corneal stem cell viability and reduce recurrence. By refining this method, we aim to offer patients a more effective and minimally invasive alternative to the gold-standard procedure.

Trial registration

ClinicalTrials.gov, NCT06402643. Registered on April 15, 2024.