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<p>Ferroptosis, an iron-dependent form of regulatory cell death driven by lipid peroxidation, has emerged as a key factor in several pathological conditions. At the organelle level, ferroptosis involves complex interactions between mitochondria, lysosome, endoplasmic reticulum (ER), Golgi apparatus, Nucleus, autophagosome, lipid droplet and peroxisome. Each of them plays a unique role in the ferroptosis cascade. Although the molecular mechanisms of ferroptosis have been extensively studied, the role of specific organelles in this process has not been fully explored. This review aims to summarize the latest advances in organelle-level changes during ferroptosis.</p>

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Organelle-specific regulation of ferroptosis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月2日

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  • Yu Zhang,
  • Mengyan Liu,
  • Min Li,
  • Yile Wu,
  • Mi Xie,
  • Xiaolong Liu,
  • Haodong Lu,
  • Xiaoyan Zhai,
  • Yanling Yang

摘要

Ferroptosis, an iron-dependent form of regulatory cell death driven by lipid peroxidation, has emerged as a key factor in several pathological conditions. At the organelle level, ferroptosis involves complex interactions between mitochondria, lysosome, endoplasmic reticulum (ER), Golgi apparatus, Nucleus, autophagosome, lipid droplet and peroxisome. Each of them plays a unique role in the ferroptosis cascade. Although the molecular mechanisms of ferroptosis have been extensively studied, the role of specific organelles in this process has not been fully explored. This review aims to summarize the latest advances in organelle-level changes during ferroptosis.