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<p>Breast cancer is the most common malignancy among women worldwide. Increasing evidence suggests that chronic exposure to pesticides, many of which act as endocrine-disrupting chemicals, represents a significant and underappreciated determinant for both cancer origin and progression. In this review, we reported the most recent epidemiological data, exposure pathways, and mechanistic insights linking major pesticide classes, including persistent organochlorines, organophosphates, triazines, carbamates, pyrethroids, neonicotinoids, and glyphosate-based herbicides, to breast carcinogenesis. These compounds are ubiquitous, detectable in food, water, household dust, and occupational environments, and display high lipophilicity that enables long-term bioaccumulation in adipose-rich breast tissue. Therefore, recognition of pesticides as modifiable environmental determinants of breast cancer should prompt strengthened regulation, improved biomonitoring, and public-health strategies aimed at reducing chronic exposure.</p>

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Effect of pesticides on breast cancer tumor

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月8日

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  • Daniele Marcoccia,
  • Stefano Palomba,
  • Giovanni Brajon,
  • Alessandro Baldi,
  • Flavia Silvia Galli,
  • Francesca Servadei,
  • Valeria Palumbo,
  • Rita Bonfiglio,
  • Michele Treglia,
  • Luigi Tonino Marsella,
  • Flavia Botti,
  • Yufang Shi,
  • Eleonora Candi,
  • Gerry Melino,
  • Alessandro Mauriello,
  • Manuel Scimeca

摘要

Breast cancer is the most common malignancy among women worldwide. Increasing evidence suggests that chronic exposure to pesticides, many of which act as endocrine-disrupting chemicals, represents a significant and underappreciated determinant for both cancer origin and progression. In this review, we reported the most recent epidemiological data, exposure pathways, and mechanistic insights linking major pesticide classes, including persistent organochlorines, organophosphates, triazines, carbamates, pyrethroids, neonicotinoids, and glyphosate-based herbicides, to breast carcinogenesis. These compounds are ubiquitous, detectable in food, water, household dust, and occupational environments, and display high lipophilicity that enables long-term bioaccumulation in adipose-rich breast tissue. Therefore, recognition of pesticides as modifiable environmental determinants of breast cancer should prompt strengthened regulation, improved biomonitoring, and public-health strategies aimed at reducing chronic exposure.