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Background <p>This study employs <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) as a model organism to explore the anti-aging effects of hydroxytyrosol (HT) and its underlying mechanisms.</p> Results <p>The findings reveal that HT significantly extends the lifespan of <i>C. elegans</i> while improving their functional performance (motility and pharyngeal function), and antioxidant capacity when administered on the first day of adulthood (D1). However, its efficacy diminishes when treatment begins on or after the third day of adulthood (D3). HT prolongs lifespan through a mechanism akin to that of <i>skn-1</i> modulating the oxidative stress pathway.</p> Conclusions <p>This study suggests that the administration timing is an important factor for of anti-oxidation compounds to be effective in counteracting aging.</p>

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Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月21日

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  • Nannan Du,
  • Lishuo Song,
  • Ruigang Yang,
  • Kexin Liu,
  • Zubiao Niu,
  • Zhanfeng Zhang,
  • Qiang Sun

摘要

Background

This study employs Caenorhabditis elegans (C. elegans) as a model organism to explore the anti-aging effects of hydroxytyrosol (HT) and its underlying mechanisms.

Results

The findings reveal that HT significantly extends the lifespan of C. elegans while improving their functional performance (motility and pharyngeal function), and antioxidant capacity when administered on the first day of adulthood (D1). However, its efficacy diminishes when treatment begins on or after the third day of adulthood (D3). HT prolongs lifespan through a mechanism akin to that of skn-1 modulating the oxidative stress pathway.

Conclusions

This study suggests that the administration timing is an important factor for of anti-oxidation compounds to be effective in counteracting aging.