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Background <p>Identifying the mechanisms of host–parasite interactions in vivo in malaria is essential for the development of antimalarial strategies tailored to clinically and physiologically relevant contexts.</p> Results <p>We analyzed 396 paired global serum lipidomes from pediatric patients sampled before and during blood-stage malaria infection in Burkina Faso, spanning three ethnic groups (Gouin, Mossi, and Fulani). Consistent infection-induced remodeling of the host lipidome was identified across populations, including depletion of 47 host-derived lipid species that correlated with parasitemia. Notably, we observed that Plasmodium falciparum selectively scavenges linoleic acid–containing phospholipids to support its proliferation and validated this with parasite culture assays. This integrative multi-omics analysis combining lipidomic profiles with host–parasite transcriptomes further identified a Plasmodium falciparum transcriptional program associated with lipid turnover in vivo.</p> Conclusions <p>These results provide a high-resolution profile of lipidomic perturbations in malarial children and demonstrate how integrated clinical phenotyping, cross-ethnic population sampling, and multi-omics can reveal key host-parasite interactions and clinically relevant metabolic changes within the human host.<!-- Query ID="Q1" Text="Please confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Author 1 Given name: [specify authors given name] Last name [specify authors last name]. Also, kindly confirm the details in the metadata are correct." --></p>

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Integrated lipidomic and transcriptomic profiling of the host response in human malaria

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月30日

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  • Wael Abdrabou,
  • Dariga Bolatbay,
  • Issiaka Soulama,
  • Maria Nikulkova,
  • Mame Massar Dieng,
  • Saruul Zorigt,
  • Manar Alshaikh,
  • Samuel Sindié Sermé,
  • Salif Sombié,
  • Noelie Bere Henry,
  • Désiré Kargougou,
  • Sam Aboubacar Coulibaly,
  • Vinu Manikandan,
  • Aïssatou Diawara,
  • Jane M. Carlton,
  • Youssef Idaghdour

摘要

Background

Identifying the mechanisms of host–parasite interactions in vivo in malaria is essential for the development of antimalarial strategies tailored to clinically and physiologically relevant contexts.

Results

We analyzed 396 paired global serum lipidomes from pediatric patients sampled before and during blood-stage malaria infection in Burkina Faso, spanning three ethnic groups (Gouin, Mossi, and Fulani). Consistent infection-induced remodeling of the host lipidome was identified across populations, including depletion of 47 host-derived lipid species that correlated with parasitemia. Notably, we observed that Plasmodium falciparum selectively scavenges linoleic acid–containing phospholipids to support its proliferation and validated this with parasite culture assays. This integrative multi-omics analysis combining lipidomic profiles with host–parasite transcriptomes further identified a Plasmodium falciparum transcriptional program associated with lipid turnover in vivo.

Conclusions

These results provide a high-resolution profile of lipidomic perturbations in malarial children and demonstrate how integrated clinical phenotyping, cross-ethnic population sampling, and multi-omics can reveal key host-parasite interactions and clinically relevant metabolic changes within the human host.