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<p>RIMap-RISC is a web-accessible database for transcriptome-wide modeling of human microRNA (miRNA) targeting. It computes plausible transcript-miRNA interactions and records their position, duplex secondary structure, free energy, site classification, dissociation constant, target accessibility, and evolutionary conservation. RIMap-RISC supports transcript-wide queries and allows users to explore and export interaction data through an interactive interface or RESTful API programmatic access. Unlike existing tools, RIMap-RISC integrates duplex-structure prediction within a biophysical framework modeling the bipartite architecture of RISC, accommodating a bridge between seed and supplementary pairing. A novel, unambiguous, miRNA-centric nomenclature for interaction types is also introduced.</p>

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RIMap-RISC: a transcriptome-wide database of structurally modeled human microRNA interactions

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月26日

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  • Simon Chasles,
  • Zakary Gaillard-Duchassin,
  • Jordan Quenneville,
  • Mélanie Lemaire,
  • Etienne Gagnon,
  • François Major

摘要

RIMap-RISC is a web-accessible database for transcriptome-wide modeling of human microRNA (miRNA) targeting. It computes plausible transcript-miRNA interactions and records their position, duplex secondary structure, free energy, site classification, dissociation constant, target accessibility, and evolutionary conservation. RIMap-RISC supports transcript-wide queries and allows users to explore and export interaction data through an interactive interface or RESTful API programmatic access. Unlike existing tools, RIMap-RISC integrates duplex-structure prediction within a biophysical framework modeling the bipartite architecture of RISC, accommodating a bridge between seed and supplementary pairing. A novel, unambiguous, miRNA-centric nomenclature for interaction types is also introduced.