Scholarlink

<p>To reach a genomic scale illustration for linkage disequilibrium (LD), we introduce X-LDR, a stochastic algorithm for biobank-scale data (<InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(\mathcal {O}(nmB)\)</EquationSource> </InlineEquation>, <i>n</i> the sample size, <i>m</i> the number of SNPs, and <i>B</i> iterations). X-LDR can scale the entire genome to high-resolution LD grids, such as nearly 9 million LD grids for UK Biobank (<InlineEquation ID="IEq2"> <EquationSource Format="TEX">\(n \approx 300,000\)</EquationSource> </InlineEquation> and <InlineEquation ID="IEq3"> <EquationSource Format="TEX">\(m\approx 4.2\)</EquationSource> </InlineEquation> million). Various characteristics of LD are discovered in terms of their biological annotation. We also present an unprecedented LD atlas for 25 reference populations that contours the diversity of interspecies LD. The algorithms have been implemented in C++.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

X-LDR: an atlas of linkage disequilibrium across species

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月20日

查看全文
  • Tian-Neng Zhu,
  • Xing Huang,
  • Meng-Yuan Yang,
  • Guo-An Qi,
  • Qi-Xin Zhang,
  • Feng Lin,
  • Wenjing Zhang,
  • Zhe Zhang,
  • Xin Jin,
  • Hou-Feng Zheng,
  • Hai-Ming Xu,
  • Shizhou Yu,
  • Guo-Bo Chen

摘要

To reach a genomic scale illustration for linkage disequilibrium (LD), we introduce X-LDR, a stochastic algorithm for biobank-scale data ( \(\mathcal {O}(nmB)\) , n the sample size, m the number of SNPs, and B iterations). X-LDR can scale the entire genome to high-resolution LD grids, such as nearly 9 million LD grids for UK Biobank ( \(n \approx 300,000\) and \(m\approx 4.2\) million). Various characteristics of LD are discovered in terms of their biological annotation. We also present an unprecedented LD atlas for 25 reference populations that contours the diversity of interspecies LD. The algorithms have been implemented in C++.