Scholarlink

<p>Multivalent interactions between proteins with intrinsically disordered regions or prion-like domains can drive liquid–liquid phase separation (LLPS) and form membraneless condensates essential for diverse cellular functions. Here, we predict phase separation scores for all annotated rice proteins and present ricePSP (<a href="https://ricepsp.github.io/">https://ricepsp.github.io/</a>), a database of phase separation-associated proteins. AlphaFold structural predictions further validate the phase separation potential of these proteins. As a proof of concept, we apply ricePSP to identify flowering-related phase separation proteins, revealing insights into how LLPS may regulate flowering. Collectively, ricePSP provides a valuable resource for studying crop phase separation proteins and LLPS-related mechanisms in crop trait regulation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

ricePSP: a database of rice phase separation-associated proteins

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月17日

查看全文
  • Runxin Gao,
  • Minrong Guo,
  • Shiping Luan,
  • Weizhi Ouyang,
  • Xingwang Li

摘要

Multivalent interactions between proteins with intrinsically disordered regions or prion-like domains can drive liquid–liquid phase separation (LLPS) and form membraneless condensates essential for diverse cellular functions. Here, we predict phase separation scores for all annotated rice proteins and present ricePSP (https://ricepsp.github.io/), a database of phase separation-associated proteins. AlphaFold structural predictions further validate the phase separation potential of these proteins. As a proof of concept, we apply ricePSP to identify flowering-related phase separation proteins, revealing insights into how LLPS may regulate flowering. Collectively, ricePSP provides a valuable resource for studying crop phase separation proteins and LLPS-related mechanisms in crop trait regulation.