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<p>We explore the concept of gene expression stability within a homeostatic cell through the gene homeostasis Z-index, a measure that highlights genes under active regulation in response to internal and external stimuli. The Z-index uncovers distinct regulatory activities and patterns driven by a small subset of cells, providing insights that traditional mean-based methods often overlook. By capturing subtle regulatory dynamics, this approach highlights the importance of stability metrics in uncovering detailed gene regulation patterns that underpin cellular adaptation.</p>

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A novel gene expression stability metric to unveil homeostasis and regulation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月10日

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  • Mengjie Chen

摘要

We explore the concept of gene expression stability within a homeostatic cell through the gene homeostasis Z-index, a measure that highlights genes under active regulation in response to internal and external stimuli. The Z-index uncovers distinct regulatory activities and patterns driven by a small subset of cells, providing insights that traditional mean-based methods often overlook. By capturing subtle regulatory dynamics, this approach highlights the importance of stability metrics in uncovering detailed gene regulation patterns that underpin cellular adaptation.