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Purpose <p>To propose a multi-parametric ultrasound imaging-based deep learning method for accurately classifying metastatic and non-metastatic axillary lymph nodes in breast cancer patients.</p> Methods <p>The proposed method integrates the conventional ultrasound B-mode imaging with shear wave elastography and color Doppler images of <b>174</b> patients to train a transfer learning-based network comprising pretrained MobileNetv2 with a custom shallow head consisting of a convolutional neural network with mixed pooling, weighted sum mixed pooling and squeeze-and-excite attention mechanisms for the first time in the context of ALN classification.</p> Results <p>The proposed method was evaluated using five-fold cross-validation, achieving a mean classification accuracy of 0.91, specificity of 0.91, sensitivity of 0.93, F1 score of 0.93, area under the precision-recall curve of 0.94, and a cross-validated AUC (cvAUC) of 0.92. A network ablation study confirmed the robustness of the model, with relatively narrow 95% confidence intervals (CIs) for cvAUC. Comparative analysis showed that the proposed network (Acc: 0.91) outperformed state-of-the-art deep learning models (Acc: 0.67–0.88) for ALN classification and exhibited narrower CIs, highlighting its relative stability. Additionally, results demonstrated that multi-parametric imaging significantly enhanced classification performance, reducing the 95% CI width by nearly half compared to uni-parametric data, further supporting the method’s robustness and reliability.</p> Conclusion <p>The integration of multi-parametric ultrasound imaging with deep learning network can remarkably improve the classification of metastatic and non-metastatic ALNs in breast cancer patients.</p> Graphical abstract <p></p>

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Deep learning-powered multi-parametric ultrasound for classifying metastatic versus reactive axillary lymph nodes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月23日

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  • Manali Saini,
  • Tanin Adl Parvar,
  • Claire Graham,
  • Nicholas B. Larson,
  • Mostafa Fatemi,
  • Azra Alizad

摘要

Purpose

To propose a multi-parametric ultrasound imaging-based deep learning method for accurately classifying metastatic and non-metastatic axillary lymph nodes in breast cancer patients.

Methods

The proposed method integrates the conventional ultrasound B-mode imaging with shear wave elastography and color Doppler images of 174 patients to train a transfer learning-based network comprising pretrained MobileNetv2 with a custom shallow head consisting of a convolutional neural network with mixed pooling, weighted sum mixed pooling and squeeze-and-excite attention mechanisms for the first time in the context of ALN classification.

Results

The proposed method was evaluated using five-fold cross-validation, achieving a mean classification accuracy of 0.91, specificity of 0.91, sensitivity of 0.93, F1 score of 0.93, area under the precision-recall curve of 0.94, and a cross-validated AUC (cvAUC) of 0.92. A network ablation study confirmed the robustness of the model, with relatively narrow 95% confidence intervals (CIs) for cvAUC. Comparative analysis showed that the proposed network (Acc: 0.91) outperformed state-of-the-art deep learning models (Acc: 0.67–0.88) for ALN classification and exhibited narrower CIs, highlighting its relative stability. Additionally, results demonstrated that multi-parametric imaging significantly enhanced classification performance, reducing the 95% CI width by nearly half compared to uni-parametric data, further supporting the method’s robustness and reliability.

Conclusion

The integration of multi-parametric ultrasound imaging with deep learning network can remarkably improve the classification of metastatic and non-metastatic ALNs in breast cancer patients.

Graphical abstract