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Background <p>β-lactam antibiotics are the most commonly used antibiotics to treat infection in critically-ill patients. The modalities of antibiotics reconstitution/preparation for continuous infusion are elaborated according to drug stability. In between 2 periods, a sustainable protocol for 4 common β-lactam antibiotics administration was implemented, consisting of preparing the highest stable concentration for continuous administration through a 50 mL syringe.</p> Results <p><i>Overall</i>,<i> 418 patients were treated (202 in 2024 and 216 in 2025)</i>,<i> age</i>,<i> and SAPSII did not differed between both periods.</i> A sustainable protocol implementation reduced the greenhouse gas emission (GHG) by 52% from 2760 [1380–4968]g to 1380 [552–2208]g/treatment, <i>p</i> &lt; 0.0001. The global reduction of plastic consumed (syringes, tubing, solution bags, blister packs) was − 48% (-61&#xa0;kg), and treatment cost was also reduced by 48% (-1324 €). The total nursing time for preparation was 145&#xa0;h shorter during the second 6 months period.</p> Discussion <p>These results showed that implementation of a sustainable protocol for continuous β-lactam antibiotics can significantly reduce the environmental impact of antibiotic administration.</p> Conclusion <p>A careful prescription of drug dilution, if continuous infusion of β-lactam antibiotics is used, can be efficient in reducing GHG emissions, consumables, waste, and costs.</p>

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Optimizing β-lactam antibiotics with the highest concentration–for continuous infusion reduce carbon footprint in intensive care

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月4日

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  • Chloé Gisbert-Mora,
  • Sandra Sablé,
  • Quentin Fossé,
  • Marc Olivier Vareil,
  • Nicolas Massart,
  • Hadrien Rozé

摘要

Background

β-lactam antibiotics are the most commonly used antibiotics to treat infection in critically-ill patients. The modalities of antibiotics reconstitution/preparation for continuous infusion are elaborated according to drug stability. In between 2 periods, a sustainable protocol for 4 common β-lactam antibiotics administration was implemented, consisting of preparing the highest stable concentration for continuous administration through a 50 mL syringe.

Results

Overall, 418 patients were treated (202 in 2024 and 216 in 2025), age, and SAPSII did not differed between both periods. A sustainable protocol implementation reduced the greenhouse gas emission (GHG) by 52% from 2760 [1380–4968]g to 1380 [552–2208]g/treatment, p < 0.0001. The global reduction of plastic consumed (syringes, tubing, solution bags, blister packs) was − 48% (-61 kg), and treatment cost was also reduced by 48% (-1324 €). The total nursing time for preparation was 145 h shorter during the second 6 months period.

Discussion

These results showed that implementation of a sustainable protocol for continuous β-lactam antibiotics can significantly reduce the environmental impact of antibiotic administration.

Conclusion

A careful prescription of drug dilution, if continuous infusion of β-lactam antibiotics is used, can be efficient in reducing GHG emissions, consumables, waste, and costs.