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Background <p>Paediatric traumatic brain injury (TBI) is a heterogeneous condition with age-dependent differences in systemic and cerebral physiology, making cerebral perfusion pressure (CPP) challenging to target. Monitoring cerebral autoregulation using the pressure reactivity index (PRx) and deriving an autoregulatory optimal CPP (CPPopt) may personalize treatment, but evidence in children remains limited. In this multicentre paediatric TBI study, we aimed to explore and visualize PRx and CPPopt in relation to outcome.</p> Methods <p>In this secondary analysis of the prospective, multicentre study (STARSHIP), 98 paediatric TBI patients (1–16 years) from 10 paediatric intensive care units, in the UK, between 2018 and 2023, with high-frequency physiological data and 12-month GOS-E Peds outcomes, not treated with decompressive craniectomy, were included. Intracranial pressure (ICP), PRx, CPP, and ΔCPPopt were correlated with outcome using insult intensity/duration heatmaps across the full monitoring period. Two-variable heatmaps incorporating PRx were also used to assess how autoregulation modified the relationship between ICP, CPP, and ΔCPPopt with outcome.</p> Results <p>There was a transition from favourable to unfavourable outcome when PRx exceeded + 0.00 for longer episodes. Furthermore, there was a transition towards worse outcome when CPP went below 40 mmHg and above 100 mmHg for sustained durations. For ΔCPPopt, the transition towards poor prognosis occurred for values below − 20 mmHg, but positive ΔCPPopt was tolerated. In the two-variable heatmaps, PRx above + 0.50 together with ICP above 20 mmHg, CPP below 60 mmHg, or negative ΔCPPopt were particularly associated with unfavourable outcome.</p> Conclusions <p>This novel study visualized the safe and dangerous intervals for PRx and CPPopt as well as the interaction effect between the autoregulatory status and ICP, CPP, and ΔCPPopt in relation to outcome in paediatric TBI. Future prospective trials are needed to evaluate the safety, feasibility, and efficacy of PRx/CPPopt guided management.</p>

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Visualizations of autoregulatory insults in moderate-to-severe paediatric traumatic brain injury: a secondary analysis from the multicentre STARSHIP trial

  • 期刊论文

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  • 发表日期：

    2025年8月4日

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  • Teodor Svedung Wettervik,
  • Claudia Ann Smith,
  • Anders Hånell,
  • Stefan Yu Bögli,
  • Peter Hutchinson,
  • Shruti Agrawal,
  • Peter Smielewski,
  • Shruti Agrawal,
  • Peter Smielewski,
  • Peter J. Hutchinson,
  • Stefan Yu B”gli,
  • Claudia A. Smith,
  • Carly Tooke,
  • Caroline Payne,
  • Holly Belfield,
  • Amisha Mistry,
  • Collette Spencer,
  • Claire Jennings,
  • Lara Bunni,
  • Laura Anderson,
  • Emily Morgan,
  • Melanie James,
  • Rebecca Beckley,
  • Tahnima Khatun,
  • Hafiza Khatun,
  • Olivia Nugent,
  • Richard Aldridge,
  • Ruth Morgan,
  • Julie Morcombe,
  • Martin Quinton,
  • Catherine Postlethwaite,
  • Jenny Pond,
  • Jessica Cutler,
  • Caitlin Oxford,
  • Marek Czosnyka,
  • Michal Placek,
  • Manuel Cabaleira,
  • Deborah White,
  • Esther Daubney,
  • Adam Young,
  • Erta Beqiri,
  • Riaz Kayani,
  • Roddy O’Donnell,
  • Nazima Pathan,
  • Suzanna Watson,
  • Anna Maw,
  • Matthew Garnett,
  • Hari Krishnan Kanthimathinathan,
  • Harish Bangalore,
  • Santosh Sundararajan,
  • Gayathri Subramanian,
  • Dusan Raffaj,
  • Simona Lampariello,
  • Avishay Sarfatti,
  • Anton Mayer,
  • Oliver Ross

摘要

Background

Paediatric traumatic brain injury (TBI) is a heterogeneous condition with age-dependent differences in systemic and cerebral physiology, making cerebral perfusion pressure (CPP) challenging to target. Monitoring cerebral autoregulation using the pressure reactivity index (PRx) and deriving an autoregulatory optimal CPP (CPPopt) may personalize treatment, but evidence in children remains limited. In this multicentre paediatric TBI study, we aimed to explore and visualize PRx and CPPopt in relation to outcome.

Methods

In this secondary analysis of the prospective, multicentre study (STARSHIP), 98 paediatric TBI patients (1–16 years) from 10 paediatric intensive care units, in the UK, between 2018 and 2023, with high-frequency physiological data and 12-month GOS-E Peds outcomes, not treated with decompressive craniectomy, were included. Intracranial pressure (ICP), PRx, CPP, and ΔCPPopt were correlated with outcome using insult intensity/duration heatmaps across the full monitoring period. Two-variable heatmaps incorporating PRx were also used to assess how autoregulation modified the relationship between ICP, CPP, and ΔCPPopt with outcome.

Results

There was a transition from favourable to unfavourable outcome when PRx exceeded + 0.00 for longer episodes. Furthermore, there was a transition towards worse outcome when CPP went below 40 mmHg and above 100 mmHg for sustained durations. For ΔCPPopt, the transition towards poor prognosis occurred for values below − 20 mmHg, but positive ΔCPPopt was tolerated. In the two-variable heatmaps, PRx above + 0.50 together with ICP above 20 mmHg, CPP below 60 mmHg, or negative ΔCPPopt were particularly associated with unfavourable outcome.

Conclusions

This novel study visualized the safe and dangerous intervals for PRx and CPPopt as well as the interaction effect between the autoregulatory status and ICP, CPP, and ΔCPPopt in relation to outcome in paediatric TBI. Future prospective trials are needed to evaluate the safety, feasibility, and efficacy of PRx/CPPopt guided management.