<p>Circulating dipeptidyl peptidase 3 is a new biomarker linked to circulatory failure prognosis and pathophysiology and is a potential actionable therapeutic target. In this short review intended for the clinician, a question-and-answer format provides key insights on the nature of this biomarker and the therapeutical potential of its targeted inhibition in critically ill patients.</p>

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Targeting high circulating dipeptidyl peptidase 3 in circulatory failure

  • Adrien Picod,
  • Feriel Azibani,
  • Veli-Pekka Harjola,
  • Mahir Karakas,
  • Antoine Kimmoun,
  • Bruno Levy,
  • Peter Pickkers,
  • Holger Thiele,
  • Uwe Zeymer,
  • Karine Santos,
  • Alexandre Mebazaa

摘要

Circulating dipeptidyl peptidase 3 is a new biomarker linked to circulatory failure prognosis and pathophysiology and is a potential actionable therapeutic target. In this short review intended for the clinician, a question-and-answer format provides key insights on the nature of this biomarker and the therapeutical potential of its targeted inhibition in critically ill patients.