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<p>This case report describes the successful treatment of a suicide attempt involving the ingestion of a supralethal dose of sodium azide (NaN<sub>3</sub>), presenting a prospective novel antidote and therapeutic approach. Treatment encompassed the implementation of high-volume continuous veno-venous hemofiltration (HV-CVVH) alongside the administration of levocarnitine. The latter demonstrated a substantial mitigation of lactate concentration. Comprehensive analyses of serum, ultrafiltrate, and urine revealed the efficacy of HV-CVVH in elimination of NaN<sub>3</sub>. Our case report presents a potential therapeutic approach for managing otherwise fatal NaN<sub>3</sub> intoxications.</p>

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Sodium azide (NaN3) intoxication, “the man who lived”: potential effective antidote and treatment strategy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月7日

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  • Jasper X. Geerdink,
  • Greetje van der Wal,
  • Lutea A. A. de Jong,
  • Erik J. H. Olyslager,
  • Thomas W. van den Goorbergh,
  • Leo A. J. Kluijtmans,
  • Peter E. Spronk

摘要

This case report describes the successful treatment of a suicide attempt involving the ingestion of a supralethal dose of sodium azide (NaN3), presenting a prospective novel antidote and therapeutic approach. Treatment encompassed the implementation of high-volume continuous veno-venous hemofiltration (HV-CVVH) alongside the administration of levocarnitine. The latter demonstrated a substantial mitigation of lactate concentration. Comprehensive analyses of serum, ultrafiltrate, and urine revealed the efficacy of HV-CVVH in elimination of NaN3. Our case report presents a potential therapeutic approach for managing otherwise fatal NaN3 intoxications.