Facial appearance associates with longitudinal multi-organ failure: an ICU cohort study

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2024年4月2日

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Eline G. M. Cox,
Bas C. T. van Bussel,
Nerea Campillo Llamazares,
Jan-Willem E. M. Sels,
Marisa Onrust,
Iwan C. C. van der Horst,
Jacqueline Koeze,
Geert Koster,
Jacqueline Koeze,
Renske Wiersema,
Frederik Keus,
Iwan C. C. van der Horst,
Willem Dieperink,
Marisa Onrust,
Nynke van der Veen,
Alexander Irk,
Arlinde Roelofs,
Leonie Tijsma,
Eline Cox,
Nerea Campillo Llamazares,
Lesley Holzhauer

摘要

Background

Facial appearance, whether consciously or subconsciously assessed, may affect clinical assessment and treatment strategies in the Intensive Care Unit (ICU). Nevertheless, the association between objective clinical measurement of facial appearance and multi-organ failure is currently unknown. The objective of this study was to examine whether facial appearance at admission is associated with longitudinal evaluation of multi-organ failure.

Methods

This was a sub-study of the Simple Intensive Care Studies-II, a prospective observational cohort study. All adult patients acutely admitted to the ICU between March 26, 2019, and July 10, 2019, were included. Facial appearance was assessed within three hours of ICU admission using predefined pictograms. The SOFA score was serially measured each day for the first seven days after ICU admission. The association between the extent of eye-opening and facial skin colour with longitudinal Sequential Organ Failure Assessment (SOFA) scores was investigated using generalized estimation equations.

Results

SOFA scores were measured in 228 patients. Facial appearance scored by the extent of eye-opening was associated with a higher SOFA score at admission and follow-up (unadjusted 0.7 points per step (95%CI 0.5 to 0.9)). There was no association between facial skin colour and a worse SOFA score over time. However, patients with half-open or closed eyes along with flushed skin had a lower SOFA score than patients with a pale or normal facial skin colour (P-interaction < 0.1).

Conclusions

The scoring of patients’ facial cues, primarily the extent of eye-opening and facial colour, provided valuable insights into the disease state and progression of the disease of critically ill patients. The utilization of advanced monitoring techniques that incorporate facial appearance holds promise for enhancing future intensive care support.