Toxicities, intensive care management, and outcome of chimeric antigen receptor T cells in adults: an update

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2024年3月5日

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Mathieu Bellal,
Jolan Malherbe,
Gandhi Damaj,
Damien Du Cheyron

摘要

Background

Chimeric antigen receptor T cells are a promising new immunotherapy for haematological malignancies. Six CAR-T cells products are currently available for adult patients with refractory or relapsed high-grade B cell malignancies, but they are associated with severe life-threatening toxicities and side effects that may require admission to ICU.

Objective

The aim of this short pragmatic review is to synthesize for intensivists the knowledge on CAR-T cell therapy with emphasis on CAR-T cell-induced toxicities and ICU management of complications according to international recommendations, outcomes and future issues.

Graphical abstract