Scholarlink

Background <p>Vaccine-preventable diseases (VPDs) are a major global health concern for children and adolescents. The COVID-19 pandemic further complicated VPDs prevention by halting vaccinations in many areas. This study aimed to analyze the global burden and trends of eight high - burden VPDs in 0 – 19 - year - olds from 1990 to 2021.</p> Methods <p>Using data from the Global Burden of Disease 2021 database across 204 countries, incidence and DALYs were stratified by age, sex, and SDI. A linear regression model calculated AAPCs, and a joinpoint regression model identified a significant trend - change years. The SII and CII quantified SDI-related burden inequality.</p> Results <p>From 1990 to 2021, global VPDs incidence and DALYs decreased. However, in 2021, there were still a large number of cases and DALYs. Hepatitis E DALYs rose, especially in males and infants. Males generally had a higher incidence of most VPDs. Lower SDI regions had heavier burdens, except for varicella and herpes zoster in high-SDI areas. The COVID-19 pandemic increased the incidence of some VPDs.</p> Conclusions <p>Despite progress in VPDs control, gaps in vaccination, socioeconomic inequalities, and new threats like hepatitis E remain. Targeted actions such as perinatal immunization, hepatitis E vaccination in endemic areas, and restoring pandemic-affected health systems are needed to achieve global health equity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Global burden and time trends of vaccine-preventable diseases in children and adolescents

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月5日

查看全文
  • Xingyi Jin,
  • Rui Wang,
  • Siying Tu,
  • Chunyan Yuan,
  • Fei Ge,
  • Yong Liu,
  • Shaokang Wang,
  • Ying Ma,
  • Guiju Sun

摘要

Background

Vaccine-preventable diseases (VPDs) are a major global health concern for children and adolescents. The COVID-19 pandemic further complicated VPDs prevention by halting vaccinations in many areas. This study aimed to analyze the global burden and trends of eight high - burden VPDs in 0 – 19 - year - olds from 1990 to 2021.

Methods

Using data from the Global Burden of Disease 2021 database across 204 countries, incidence and DALYs were stratified by age, sex, and SDI. A linear regression model calculated AAPCs, and a joinpoint regression model identified a significant trend - change years. The SII and CII quantified SDI-related burden inequality.

Results

From 1990 to 2021, global VPDs incidence and DALYs decreased. However, in 2021, there were still a large number of cases and DALYs. Hepatitis E DALYs rose, especially in males and infants. Males generally had a higher incidence of most VPDs. Lower SDI regions had heavier burdens, except for varicella and herpes zoster in high-SDI areas. The COVID-19 pandemic increased the incidence of some VPDs.

Conclusions

Despite progress in VPDs control, gaps in vaccination, socioeconomic inequalities, and new threats like hepatitis E remain. Targeted actions such as perinatal immunization, hepatitis E vaccination in endemic areas, and restoring pandemic-affected health systems are needed to achieve global health equity.