Scholarlink

Background <p>This study aimed to explore the function and clinical significance of peripheral blood CD8 + T cells in EBV-associated infectious mononucleosis (IM).</p> Methods <p>From June 2022 to May 2024, blood samples of 48 IM children and 24 healthy controls were collected. ELISA detected IFN-γ, IL-10, TGF-β1 levels, and RT-PCR measured perforin and granzyme B mRNA levels.</p> Results <p>results showed higher white blood cell, lymphocyte counts, etc. in the case group. Also, more CD3+, CD3 + CD8+ and NK cells, lower CD4+/CD8 + ratio were found in cases. IFN-γ, IL-10, perforin, granzyme B were higher, while TGF-β1 was lower in cases. Some negative and positive correlations were found among cytokines and cell counts.</p> Conclusion <p>CD8 + T cells and their related cytokines IFN-γ, IL-10, TGF-β1, perforin and granzyme B are involved in the immune process of infectious mononucleosis related to EBV.</p> Clinical trial number <p>Not applicable.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Functional study of peripheral blood CD8 + T cells in Epstein-Barr virus-associated infectious mononucleosis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月16日

查看全文
  • Meng Cao,
  • Mengli Xu,
  • Yuewen Su,
  • Jun Xu,
  • Zhenghua Ji,
  • Qinghui Chen,
  • Yuqin Li,
  • Weifang Zhou

摘要

Background

This study aimed to explore the function and clinical significance of peripheral blood CD8 + T cells in EBV-associated infectious mononucleosis (IM).

Methods

From June 2022 to May 2024, blood samples of 48 IM children and 24 healthy controls were collected. ELISA detected IFN-γ, IL-10, TGF-β1 levels, and RT-PCR measured perforin and granzyme B mRNA levels.

Results

results showed higher white blood cell, lymphocyte counts, etc. in the case group. Also, more CD3+, CD3 + CD8+ and NK cells, lower CD4+/CD8 + ratio were found in cases. IFN-γ, IL-10, perforin, granzyme B were higher, while TGF-β1 was lower in cases. Some negative and positive correlations were found among cytokines and cell counts.

Conclusion

CD8 + T cells and their related cytokines IFN-γ, IL-10, TGF-β1, perforin and granzyme B are involved in the immune process of infectious mononucleosis related to EBV.

Clinical trial number

Not applicable.