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<p>Atopic dermatitis is a compelling challenge in daily practice. Type 2 inflammation is the most common endotype in children and adolescents with AD. As a result, anti-inflammatory drugs, mainly corticosteroids (CS) and immunomodulatory agents, represent the first-line treatment to dampen type 2 inflammation. However, biologics, particularly dupilumab, dramatically changed the natural history of AD patients. A steering committee composed by expert pediatricians and dermatologists promoted a multidisciplinary Delphi Consensus to improve the knowledge about this topic. Experts in this field participated in the Consensus of three groups of statements concerning definition, diagnosis, and management. There was agreement for all proposed statements. The outcomes of the present multidisciplinary Delphi Consensus propose shared, evidence-based recommendations that may be fruitful in clinical practice.</p>

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Multidisciplinary Delphi Consensus on management of children with moderate-severe atopic dermatitis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月20日

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  • Gian Luigi Marseglia,
  • Maria Angela Tosca,
  • Michele Miraglia del Giudice,
  • Anna Belloni Fortina,
  • Domenico Bonamonte,
  • Iria Neri,
  • Diego G. Peroni,
  • Antonio D’Avino,
  • Pasquale Comberiati,
  • Cesare Filippeschi,
  • Sara Manti,
  • Elena Galli,
  • Francesca Mori,
  • Carlo Caffarelli,
  • Amelia Licari,
  • Giorgio Ciprandi

摘要

Atopic dermatitis is a compelling challenge in daily practice. Type 2 inflammation is the most common endotype in children and adolescents with AD. As a result, anti-inflammatory drugs, mainly corticosteroids (CS) and immunomodulatory agents, represent the first-line treatment to dampen type 2 inflammation. However, biologics, particularly dupilumab, dramatically changed the natural history of AD patients. A steering committee composed by expert pediatricians and dermatologists promoted a multidisciplinary Delphi Consensus to improve the knowledge about this topic. Experts in this field participated in the Consensus of three groups of statements concerning definition, diagnosis, and management. There was agreement for all proposed statements. The outcomes of the present multidisciplinary Delphi Consensus propose shared, evidence-based recommendations that may be fruitful in clinical practice.