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Background <p>To analyze the clinical characteristics of children with adenoviral pneumonia, identify independent risk factors for early prediction of plastic bronchiolitis (PB), and develop a predictive nomogram.</p> Methods <p>This retrospective study analyzed the clinical data of children diagnosed with adenoviral pneumonia. Patients were categorized into PB and non-PB groups. General characteristics, clinical symptoms, laboratory findings, and imaging results were compared between the two groups. Multivariate logistic regression was used to identify significant risk factors, and a nomogram model was constructed.</p> Results <p>Among the 164 patients, 139 were in the non-PB group and 25 were in the PB group. Multivariate logistic regression identified diminished breath sounds, D-dimer (D-D) levels, and Lactic dehydrogenase (LDH) levels as significant risk factors for PB. The nomogram developed from these factors had an area under the receiver operating characteristic curve (AUC) of 0.904 (95% confidence interval: 0.847–0.960). The Hosmer-Lemeshow test showed good calibration (<i>p</i> = 0.515, X<sup>2</sup> = 7.207).</p> Conclusions <p>Diminished breath sounds, D-D levels, and LDH levels are independent risk factors for PB in children with adenoviral pneumonia. The developed nomogram demonstrates high predictive accuracy and good calibration, providing a valuable tool for early prediction and clinical decision-making. Future studies should validate this nomogram in larger and diverse populations.</p>

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Clinical features and risk factors of adenovirus-related plastic bronchitis in children

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月27日

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  • Yifan Wang,
  • Yuhan Jiang,
  • Ruiwen Xia,
  • Xin Cong,
  • Ning Zhang,
  • Wanyi Li,
  • Xuelin Wang,
  • Ying-Xue Zou

摘要

Background

To analyze the clinical characteristics of children with adenoviral pneumonia, identify independent risk factors for early prediction of plastic bronchiolitis (PB), and develop a predictive nomogram.

Methods

This retrospective study analyzed the clinical data of children diagnosed with adenoviral pneumonia. Patients were categorized into PB and non-PB groups. General characteristics, clinical symptoms, laboratory findings, and imaging results were compared between the two groups. Multivariate logistic regression was used to identify significant risk factors, and a nomogram model was constructed.

Results

Among the 164 patients, 139 were in the non-PB group and 25 were in the PB group. Multivariate logistic regression identified diminished breath sounds, D-dimer (D-D) levels, and Lactic dehydrogenase (LDH) levels as significant risk factors for PB. The nomogram developed from these factors had an area under the receiver operating characteristic curve (AUC) of 0.904 (95% confidence interval: 0.847–0.960). The Hosmer-Lemeshow test showed good calibration (p = 0.515, X2 = 7.207).

Conclusions

Diminished breath sounds, D-D levels, and LDH levels are independent risk factors for PB in children with adenoviral pneumonia. The developed nomogram demonstrates high predictive accuracy and good calibration, providing a valuable tool for early prediction and clinical decision-making. Future studies should validate this nomogram in larger and diverse populations.