Scholarlink

Background <p>The Omicron variant has heightened COVID- 19 infections among children under six, emphasizing the need to understand the role of parental immunization and demographic factors in disease transmission within households.</p> Methods <p>This retrospective observational study included 2321 children under six-year-old from February to May 2022 in Isfahan, Iran. Data were sourced from the recorded PERSIAN Birth Cohort data and telephone interviews, focusing on demographic information, child's COVID- 19 exposure during follow-up, infection, and vaccination status of each family member.</p> Result <p>Out of 2321 children, the incidence rate of COVID- 19 during the sixth peak was determined to be 46%. Both maternal (X<sup>2</sup>: 1237.0; <i>p</i>-value &lt; 0.001) and paternal (X<sup>2</sup>: 1003.1; <i>p</i>-value &lt; 0.001) COVID- 19 infections were identified as significant risk factors for infection of children.</p> <p>Although paternal vaccination showed a statistically significant association with reduced infection rates among children (<i>p</i> = 0.036), maternal immunization did not demonstrate a significantly correlation. After Adjusting covariates, higher odds of child COVID- 19 incidence were associated with maternal infection (OR = 37.74, 95%CI: 24.86- 57.27), paternal infection (OR = 6.50,95% CI: 4.74–8.92), and maternal age older than 30 years old (odds ratio: 0.58, 95% CI: 0.49 to 0.68). Additionally, lower odds of infection were related to living at homes with optimal cleanness (odds ratio: 0.8, 95% CI: 0.6 to 0.9). Although in a crude model, the odds of infection of children in low-income families was 60% more than in moderate- or high-income families; this probability was not statistically significant in the adjusted model.</p> Conclusion <p>This study underscores the significant role of parental transmission and paternal immunization in child COVID- 19 infections and the dimension of infection rates during the Omicron peak. Regarding the occupational conditions of fathers in our society and the characteristics of the COVID- 19 virus, paternal immunization should be prioritized over maternal immunization to mitigate disease transmission. Also, the sanitation of the home is crucial to prevent of risk of infection in children.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The association of COVID- 19 parental immunization and transmission of disease to offspring: a retrospective study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月30日

查看全文
  • Milad Maghsoudi,
  • Majid Keivanfar,
  • Seyede Shahrbanoo Daniali,
  • Roya Kelishadi

摘要

Background

The Omicron variant has heightened COVID- 19 infections among children under six, emphasizing the need to understand the role of parental immunization and demographic factors in disease transmission within households.

Methods

This retrospective observational study included 2321 children under six-year-old from February to May 2022 in Isfahan, Iran. Data were sourced from the recorded PERSIAN Birth Cohort data and telephone interviews, focusing on demographic information, child's COVID- 19 exposure during follow-up, infection, and vaccination status of each family member.

Result

Out of 2321 children, the incidence rate of COVID- 19 during the sixth peak was determined to be 46%. Both maternal (X2: 1237.0; p-value < 0.001) and paternal (X2: 1003.1; p-value < 0.001) COVID- 19 infections were identified as significant risk factors for infection of children.

Although paternal vaccination showed a statistically significant association with reduced infection rates among children (p = 0.036), maternal immunization did not demonstrate a significantly correlation. After Adjusting covariates, higher odds of child COVID- 19 incidence were associated with maternal infection (OR = 37.74, 95%CI: 24.86- 57.27), paternal infection (OR = 6.50,95% CI: 4.74–8.92), and maternal age older than 30 years old (odds ratio: 0.58, 95% CI: 0.49 to 0.68). Additionally, lower odds of infection were related to living at homes with optimal cleanness (odds ratio: 0.8, 95% CI: 0.6 to 0.9). Although in a crude model, the odds of infection of children in low-income families was 60% more than in moderate- or high-income families; this probability was not statistically significant in the adjusted model.

Conclusion

This study underscores the significant role of parental transmission and paternal immunization in child COVID- 19 infections and the dimension of infection rates during the Omicron peak. Regarding the occupational conditions of fathers in our society and the characteristics of the COVID- 19 virus, paternal immunization should be prioritized over maternal immunization to mitigate disease transmission. Also, the sanitation of the home is crucial to prevent of risk of infection in children.