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Background <p>In recent months, <i>Bordetella pertussis</i> has reappeared after maintaining a low rate for many years. Although pertussis is usually characterized by a favorable course, several factors can contribute to the severity of the disease, such as mixed respiratory infections. In this study, we evaluate <i>B.pertussis</i> cases observed in the pediatric population followed at the Bambino Gesù Children's Hospital and analyzed the potential impact of co-infections in relation to disease severity.</p> Methods <p>From January to May 2024, a total of 1,151 children and adolescents (both inpatients and outpatients) were screened for the presence of respiratory pathogens, including <i>B.pertussis,</i> with clinically relevant respiratory symptoms.</p> Results <p>Among the 1,151 patients screened, 66 tested positive for <i>B.pertussis</i>. Fourteen patients had respiratory failure, and six of them required intensive care unit (ICU) admission, while 52 had mild infection. 23.3% of patients had <i>B.pertussis</i> alone, while 76.7% had co-infections (including 5 patients admitted to the ICU). A higher co-infection rate was observed in patients with respiratory failure than in those without failure (92.9% vs. 69.0%, <i>p</i>-value:0.041). Rhinovirus, Metapneumovirus and Parainfluenza-virus were the most prevalent in our pediatric population. Co-infections of human bocavirus with <i>B.pertussis</i> were observed exclusively in patients with respiratory failure.</p> Conclusions <p>Our results highlighted an increase in <i>B.pertussis</i> cases from January to May 2024, reaching a peak of cases in the month of May. This study shows a high rate of <i>B.pertussis</i> co-infection, and a trend toward association between <i>B.pertussis</i> and specific viruses, that might play a role in increasing disease severity.</p>

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A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月21日

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  • Rossana Scutari,
  • Giulia Linardos,
  • Stefania Ranno,
  • Mara Pisani,
  • Anna Chiara Vittucci,
  • Luana Coltella,
  • Luna Colagrossi,
  • Velia Chiara Di Maio,
  • Annamaria Sisto,
  • Livia Mancinelli,
  • Simona Landi,
  • Sebastian Cristaldi,
  • Massimiliano Raponi,
  • Paola Bernaschi,
  • Alberto Villani,
  • Cristina Russo,
  • Carlo Federico Perno

摘要

Background

In recent months, Bordetella pertussis has reappeared after maintaining a low rate for many years. Although pertussis is usually characterized by a favorable course, several factors can contribute to the severity of the disease, such as mixed respiratory infections. In this study, we evaluate B.pertussis cases observed in the pediatric population followed at the Bambino Gesù Children's Hospital and analyzed the potential impact of co-infections in relation to disease severity.

Methods

From January to May 2024, a total of 1,151 children and adolescents (both inpatients and outpatients) were screened for the presence of respiratory pathogens, including B.pertussis, with clinically relevant respiratory symptoms.

Results

Among the 1,151 patients screened, 66 tested positive for B.pertussis. Fourteen patients had respiratory failure, and six of them required intensive care unit (ICU) admission, while 52 had mild infection. 23.3% of patients had B.pertussis alone, while 76.7% had co-infections (including 5 patients admitted to the ICU). A higher co-infection rate was observed in patients with respiratory failure than in those without failure (92.9% vs. 69.0%, p-value:0.041). Rhinovirus, Metapneumovirus and Parainfluenza-virus were the most prevalent in our pediatric population. Co-infections of human bocavirus with B.pertussis were observed exclusively in patients with respiratory failure.

Conclusions

Our results highlighted an increase in B.pertussis cases from January to May 2024, reaching a peak of cases in the month of May. This study shows a high rate of B.pertussis co-infection, and a trend toward association between B.pertussis and specific viruses, that might play a role in increasing disease severity.