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<p>Polycystic ovary syndrome (PCOS) is a prevalent endocrine-metabolic disorder in which gut dysbiosis acts as a key environmental driver. This review synthesizes how probiotics and prebiotics remodel the gut ecosystem and ameliorate PCOS through multi-pathway mechanisms:restoring intestinal barrier function, modulating microbial metabolites (e.g., short-chain fatty acids(SCFAs), bile acids(BAs)), attenuating chronic inflammation, and regulating androgen metabolism. We further propose a novel “integrated microbiome‑centric management” framework, demonstrating how microbiota-targeted interventions synergize with dietary, pharmacological, and behavioral strategies to enable personalized, multi-modal PCOS care. This work provides a transformative perspective for translating gut microbiome science into clinical practice across disciplinary boundaries.</p> Graphical Abstract <p></p>

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Targeting the gut microbiome: an integrated probiotic and prebiotic strategy for polycystic ovary syndrome management

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月15日

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  • Muchu Ni,
  • Qin Wang,
  • Tao Ye,
  • Hongyan Lei,
  • Yongzhou Wang,
  • Yuan Yuan

摘要

Polycystic ovary syndrome (PCOS) is a prevalent endocrine-metabolic disorder in which gut dysbiosis acts as a key environmental driver. This review synthesizes how probiotics and prebiotics remodel the gut ecosystem and ameliorate PCOS through multi-pathway mechanisms:restoring intestinal barrier function, modulating microbial metabolites (e.g., short-chain fatty acids(SCFAs), bile acids(BAs)), attenuating chronic inflammation, and regulating androgen metabolism. We further propose a novel “integrated microbiome‑centric management” framework, demonstrating how microbiota-targeted interventions synergize with dietary, pharmacological, and behavioral strategies to enable personalized, multi-modal PCOS care. This work provides a transformative perspective for translating gut microbiome science into clinical practice across disciplinary boundaries.

Graphical Abstract