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<p>Yin-deficiency and Yang-deficiency, key concepts in traditional Chinese medicine, are linked to various health conditions, but their molecular mechanisms are not well understood. High-grade serous ovarian cancer (HGSOC) is a malignancy with high mortality, and the impact of these deficiencies on the disease’s progression and patient outcomes is unknown. This study investigates the impact of these deficiencies on HGSOC by examining the molecular and cellular differences between balance, Yin-deficiency, and Yang-deficiency states. We performed differential gene expression analysis to compare the transcriptomes of these states, conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, and used LASSO regression to classify subjects. Survival analysis assessed the prognostic significance of Yin-deficiency in HGSOC, and immune cell infiltration was analyzed to understand underlying cellular mechanisms. Drug screening was conducted to identify potential therapies targeting Yin-deficiency-related gene expression changes. We identified 374 differentially expressed genes (DEGs) in Yin-deficiency and 398 DEGs in Yang-deficiency subjects. The DEGs were enriched in pathways related to protein methylation, immune response, and metabolism. Survival analysis revealed that Yin-deficiency is associated with poorer prognosis (HR 1.5, 95% CI 1.05–2.20) in HGSOC. Immune cell analysis revealed distinct profiles in Yin-deficiency patients. The gene <i>Napepld</i> was identified as a candidate biomarker of chemotherapy response. Drug screening identified candidate drug anisomycin that could potentially enhance apoptosis, decrease exosome, and down-regulate <i>Napepld</i>. This study highlights Yin-deficiency as an associated prognostic factor and identifies potential markers and therapies for targeted treatment in HGSOC.</p>

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From Yin-deficiency to therapy: molecular mechanisms and drug discovery in high-grade serous ovarian cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月17日

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  • Ling Wu,
  • Peihong Lin,
  • Xuedan Lai,
  • Yufang Lin,
  • Zhuoling Jiang

摘要

Yin-deficiency and Yang-deficiency, key concepts in traditional Chinese medicine, are linked to various health conditions, but their molecular mechanisms are not well understood. High-grade serous ovarian cancer (HGSOC) is a malignancy with high mortality, and the impact of these deficiencies on the disease’s progression and patient outcomes is unknown. This study investigates the impact of these deficiencies on HGSOC by examining the molecular and cellular differences between balance, Yin-deficiency, and Yang-deficiency states. We performed differential gene expression analysis to compare the transcriptomes of these states, conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, and used LASSO regression to classify subjects. Survival analysis assessed the prognostic significance of Yin-deficiency in HGSOC, and immune cell infiltration was analyzed to understand underlying cellular mechanisms. Drug screening was conducted to identify potential therapies targeting Yin-deficiency-related gene expression changes. We identified 374 differentially expressed genes (DEGs) in Yin-deficiency and 398 DEGs in Yang-deficiency subjects. The DEGs were enriched in pathways related to protein methylation, immune response, and metabolism. Survival analysis revealed that Yin-deficiency is associated with poorer prognosis (HR 1.5, 95% CI 1.05–2.20) in HGSOC. Immune cell analysis revealed distinct profiles in Yin-deficiency patients. The gene Napepld was identified as a candidate biomarker of chemotherapy response. Drug screening identified candidate drug anisomycin that could potentially enhance apoptosis, decrease exosome, and down-regulate Napepld. This study highlights Yin-deficiency as an associated prognostic factor and identifies potential markers and therapies for targeted treatment in HGSOC.