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Background <p>Numerous studies have explored the impact of coronavirus disease 2019 (COVID-19) on endocrine and metabolic functions, yet research targeting the population with pathological ovarian aging (POA) remains scarce. The aim of our study was therefore to explore the influence of COVID-19 on ovarian function, thyroid function, liver function, and lipid profiles in women with POA.</p> Design <p>Nested, self-controlled study.</p> Results <p>This is an observational self-controlled study. 141 women diagnosed with COVID-19 during the study period were recruited from the prospective Chinese Ovarian Aging Cohort (COACH). After being infected with COVID-19, patients with POA presented further reproductive hormone dysregulation as evaluated by significantly decreased estradiol (E2) (22.4 [IQR 7.8–62.1] pg/mL vs. 16.9 [IQR 6.2–51.9] pg/mL, <i>P</i> = 0.034) and inhibin B (INHB) (16.3 [IQR 10.0-23.6] pg/mL vs. 12.3 [IQR 10.0–21.0] pg/mL, <i>P</i> = 0.029) concentrations. In addition, patients with POA may experience thyroid dysfunction, liver dysfunction, and lipid metabolism disorders after SARS-CoV-2 infection, as indicated by significantly decreased triiodothyronine (FT3) levels, and significantly increased aspartate transaminase (AST) and total cholesterol (TC) levels (all <i>P</i> &lt; 0.05). We performed subgroup analyses stratified by age to determine whether POA patients of different age groups exhibit different endocrine and metabolic responses to SARS-CoV-2 infection. The levels of E2 (25.5 [IQR 9.3–77.6] pg/mL vs. 14.6 [IQR 5.1–37.9] pg/mL, <i>P</i> = 0.006) and INHB (16.9 [IQR 10.0-25.1] pg/mL vs. 10.7 [IQR 10.0–22.0] pg/mL, <i>P</i> = 0.012) were significantly decreased after SARS-CoV-2 infection in women younger than 35 years. In both subgroups, the level of FT3 was significantly decreased after SARS-CoV-2 infection, whereas the level of TC was significantly increased after SARS-CoV-2 infection, independent of age (all <i>P</i> &lt; 0.05).</p> Conclusions <p>This study provides preliminary clinical evidence that patients with POA and confirmed SARS-CoV-2 infection may experience further reproductive hormone dysregulation, along with thyroid dysfunction, liver dysfunction, and lipid disorders, facilitating improved clinical management.</p>

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Influence of COVID-19 on endocrine and metabolic profiles in women with pathological ovarian aging

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月14日

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  • Hui Jiang,
  • Rongrong Zhang,
  • Shutong Meng,
  • Tingting Meng,
  • Changjing Wang,
  • Wei Luo,
  • Jiangtao Zhang,
  • Jing Zhang,
  • Runxin Yao,
  • Zi-Jiang Chen,
  • Peihao Liu,
  • Xue Jiao,
  • Yingying Qin

摘要

Background

Numerous studies have explored the impact of coronavirus disease 2019 (COVID-19) on endocrine and metabolic functions, yet research targeting the population with pathological ovarian aging (POA) remains scarce. The aim of our study was therefore to explore the influence of COVID-19 on ovarian function, thyroid function, liver function, and lipid profiles in women with POA.

Design

Nested, self-controlled study.

Results

This is an observational self-controlled study. 141 women diagnosed with COVID-19 during the study period were recruited from the prospective Chinese Ovarian Aging Cohort (COACH). After being infected with COVID-19, patients with POA presented further reproductive hormone dysregulation as evaluated by significantly decreased estradiol (E2) (22.4 [IQR 7.8–62.1] pg/mL vs. 16.9 [IQR 6.2–51.9] pg/mL, P = 0.034) and inhibin B (INHB) (16.3 [IQR 10.0-23.6] pg/mL vs. 12.3 [IQR 10.0–21.0] pg/mL, P = 0.029) concentrations. In addition, patients with POA may experience thyroid dysfunction, liver dysfunction, and lipid metabolism disorders after SARS-CoV-2 infection, as indicated by significantly decreased triiodothyronine (FT3) levels, and significantly increased aspartate transaminase (AST) and total cholesterol (TC) levels (all P < 0.05). We performed subgroup analyses stratified by age to determine whether POA patients of different age groups exhibit different endocrine and metabolic responses to SARS-CoV-2 infection. The levels of E2 (25.5 [IQR 9.3–77.6] pg/mL vs. 14.6 [IQR 5.1–37.9] pg/mL, P = 0.006) and INHB (16.9 [IQR 10.0-25.1] pg/mL vs. 10.7 [IQR 10.0–22.0] pg/mL, P = 0.012) were significantly decreased after SARS-CoV-2 infection in women younger than 35 years. In both subgroups, the level of FT3 was significantly decreased after SARS-CoV-2 infection, whereas the level of TC was significantly increased after SARS-CoV-2 infection, independent of age (all P < 0.05).

Conclusions

This study provides preliminary clinical evidence that patients with POA and confirmed SARS-CoV-2 infection may experience further reproductive hormone dysregulation, along with thyroid dysfunction, liver dysfunction, and lipid disorders, facilitating improved clinical management.