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Background <p>Only small-sample retrospective studies have been performed to assess the efficacy of current treatment modalities for adult-type ovarian granulosa cell tumor. Therefore, we retrospectively evaluated patients with stage I AGCT admitted to our center over the past two decades and systematically analyzed the impact of different surgical modalities on the survival of these patients.</p> Methods <p>All patients with stage I AGCT treated in Sun Yat-sen University Cancer Center from May 1998 to April 2020 were enrolled and analyzed in this retrospective study.</p> Results <p>A total of 101 patients with stage I AGCT were identified, among whom 49 were stage Ia and 52 were stage Ic. The median follow up was 47.7 months. The 10-year cancer specific survival (CSS) and disease-free survival (DFS) rates were 90% and 53%, respectively. Multivariate analysis showed that only surgical extent (conservative vs. radical, HR: 2.738, p-value = 0.034) was an independent prognostic factor for disease-free survival. Subgroup analysis suggested that both surgical extent and surgical approach had a significant impact on the disease-free survival of patients with stage Ic (conservative vs. radical, HR: 4.021, p-value = 0.007; laparoscopic vs. open, HR: 2.926, p-value = 0.035) and tumor larger than 5&#xa0;cm (conservative vs. radical, HR: 4.437, p-value = 0.001; laparoscopic vs. open, HR: 3.367, p-value = 0.006).</p> Conclusions <p>Patients with stage I AGCT generally have a favorable prognosis. Surgical extent is an independent prognostic factor. For high risk patients with stage Ic disease or tumor larger than 5&#xa0;cm, our study supports the selection of radical and open surgery as a potentially preferred option.</p>

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Impact of surgical modalities on the survival of stage I adult–type ovarian granulosa cell tumor: a comprehensive analysis of 101 cases

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月29日

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  • Qingna Chen,
  • Lili Liu,
  • Jiaqi Qiu,
  • Huijuan He,
  • Hua Tu,
  • Haifeng Gu

摘要

Background

Only small-sample retrospective studies have been performed to assess the efficacy of current treatment modalities for adult-type ovarian granulosa cell tumor. Therefore, we retrospectively evaluated patients with stage I AGCT admitted to our center over the past two decades and systematically analyzed the impact of different surgical modalities on the survival of these patients.

Methods

All patients with stage I AGCT treated in Sun Yat-sen University Cancer Center from May 1998 to April 2020 were enrolled and analyzed in this retrospective study.

Results

A total of 101 patients with stage I AGCT were identified, among whom 49 were stage Ia and 52 were stage Ic. The median follow up was 47.7 months. The 10-year cancer specific survival (CSS) and disease-free survival (DFS) rates were 90% and 53%, respectively. Multivariate analysis showed that only surgical extent (conservative vs. radical, HR: 2.738, p-value = 0.034) was an independent prognostic factor for disease-free survival. Subgroup analysis suggested that both surgical extent and surgical approach had a significant impact on the disease-free survival of patients with stage Ic (conservative vs. radical, HR: 4.021, p-value = 0.007; laparoscopic vs. open, HR: 2.926, p-value = 0.035) and tumor larger than 5 cm (conservative vs. radical, HR: 4.437, p-value = 0.001; laparoscopic vs. open, HR: 3.367, p-value = 0.006).

Conclusions

Patients with stage I AGCT generally have a favorable prognosis. Surgical extent is an independent prognostic factor. For high risk patients with stage Ic disease or tumor larger than 5 cm, our study supports the selection of radical and open surgery as a potentially preferred option.