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<p>In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing a particularly promising avenue of investigation. The identification of ncRNA-encoded peptides in human cancers is increasing. These peptides regulate cancer progression through multiple molecular mechanisms. Here, we delineate the patterns of diverse ncRNA-encoded peptides and provide a synopsis of the methodologies employed for the identification of ncRNAs that possess the capacity to encode these peptides. Furthermore, we discuss the impacts of ncRNA-encoded peptides on the biological behavior of cancer cells and the underlying molecular mechanisms. In conclusion, we describe the prospects of ncRNA-encoded peptides in cancer and the challenges that need to be overcome.</p>

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Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月19日

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  • Shiming Tan,
  • Wenjuan Yang,
  • Zongyao Ren,
  • Qiu Peng,
  • Xuemeng Xu,
  • Xianjie Jiang,
  • Zhu Wu,
  • Linda Oyang,
  • Xia Luo,
  • Jinguan Lin,
  • Longzheng Xia,
  • Mingjing Peng,
  • Nayiyuan Wu,
  • Yanyan Tang,
  • Yaqian Han,
  • Qianjin Liao,
  • Yujuan Zhou

摘要

In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing a particularly promising avenue of investigation. The identification of ncRNA-encoded peptides in human cancers is increasing. These peptides regulate cancer progression through multiple molecular mechanisms. Here, we delineate the patterns of diverse ncRNA-encoded peptides and provide a synopsis of the methodologies employed for the identification of ncRNAs that possess the capacity to encode these peptides. Furthermore, we discuss the impacts of ncRNA-encoded peptides on the biological behavior of cancer cells and the underlying molecular mechanisms. In conclusion, we describe the prospects of ncRNA-encoded peptides in cancer and the challenges that need to be overcome.