Continuous therapy in HHV-8 negative Multicentric Castleman Disease and prolonged progression-free survival

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2024年8月6日

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Yi Liu,
Xuejiao Yin,
Shengnan Ding,
Jiaying Ge,
Liya Ma,
Min Yang,
Xuxia Luo,
Chengli Zhong,
Sishi Fang,
Qiumei Yao,
Li Zhu,
Wenjuan Yu,
Liping Mao,
Juying Wei,
Xingnong Ye,
De Zhou,
Hongyan Tong,
Haitao Meng,
Jie Jin,
Liangshun You

摘要

The optimal treatment endpoints and duration of continuous therapy for multicentric Castleman disease (MCD) remain controversial. We retrospectively analyzed data from 123 patients with Human Herpesvirus (HHV)-8 negative MCD. We demonstrated that continuous therapy significantly enhanced progression-free survival (PFS) in patients who achieved an optimal response after initial treatment. These findings underscore the critical role of continuous therapy in HHV-8 negative MCD. Further studies with larger cohorts are required to validate these findings.