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<p>Cutaneous oncology needs to be treated locally with maximal exposure to the target with minimum systemic toxicity. Novasomes, surfactant-rich vesicles, have proven to be promising theranostic carriers for both topical and intralesional delivery. This review aims to establish a translational framework linking novasome design with theranostic-guided dosing in cutaneous oncology. A literature search of publications from the time period 2010–2026 was conducted in Scopus, PubMed, and Web of Science to capture studies on formulation, in vitro/ex vivo penetration data, in vivo efficacy, and biodistribution, and the first clinical reports; the priority was given to studies with orthogonal imaging, microdialysis, and/ or IND-relevant endpoints. The literature shows that novasomes allow improved local drug retention, controllable release kinetics, and better follicular and tumor penetration than traditional topical systems. Surface modification and deformable bilayers also help further optimise targeting, and co-loading imaging agents enables real-time visualisation, image-guided dosing, and adaptive PK/PD modelling. Advances in scalable fabrication techniques such as microfluidics and solvent-minimized processes enhance translational feasibility. However, there are still challenges in long-term stability, standardized reporting of critical quality attributes, and regulatory harmonization. In conclusion, novasomes are a pragmatic and modular platform for localized image-guided cutaneous oncology. A unique aspect of this review is the inclusion of novasome formulation strategies, theranostic functions, and concepts of PK/PD-guided dosing in a translational context for cutaneous oncology. The review bridges the gap between formulation development and clinical implementation aspects, thereby offering a practical view for future precision nanomedicine strategies.</p> Graphical Abstract <p></p>

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Translational design of multifunctional novasomes for theranostic-driven precision therapy of cutaneous oncology

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月5日

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  • Md. Azhar,
  • Rishabha Malviya,
  • Phool Chandra,
  • Sathvik Belagodu Sridhar,
  • Javedh Shareef,
  • Tarun Wadhwa,
  • Daniel Arockiam

摘要

Cutaneous oncology needs to be treated locally with maximal exposure to the target with minimum systemic toxicity. Novasomes, surfactant-rich vesicles, have proven to be promising theranostic carriers for both topical and intralesional delivery. This review aims to establish a translational framework linking novasome design with theranostic-guided dosing in cutaneous oncology. A literature search of publications from the time period 2010–2026 was conducted in Scopus, PubMed, and Web of Science to capture studies on formulation, in vitro/ex vivo penetration data, in vivo efficacy, and biodistribution, and the first clinical reports; the priority was given to studies with orthogonal imaging, microdialysis, and/ or IND-relevant endpoints. The literature shows that novasomes allow improved local drug retention, controllable release kinetics, and better follicular and tumor penetration than traditional topical systems. Surface modification and deformable bilayers also help further optimise targeting, and co-loading imaging agents enables real-time visualisation, image-guided dosing, and adaptive PK/PD modelling. Advances in scalable fabrication techniques such as microfluidics and solvent-minimized processes enhance translational feasibility. However, there are still challenges in long-term stability, standardized reporting of critical quality attributes, and regulatory harmonization. In conclusion, novasomes are a pragmatic and modular platform for localized image-guided cutaneous oncology. A unique aspect of this review is the inclusion of novasome formulation strategies, theranostic functions, and concepts of PK/PD-guided dosing in a translational context for cutaneous oncology. The review bridges the gap between formulation development and clinical implementation aspects, thereby offering a practical view for future precision nanomedicine strategies.

Graphical Abstract