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Background <p>The distribution of high-risk human papillomavirus (hrHPV) genotypes varies across populations and directly influences cervical cancer prevention strategies. Data from underserved rural populations remain limited.</p> Methods <p>A community-based screening study was conducted among 358 women from rural and tribal regions of Kerala, India. High-risk HPV was detected using real-time PCR, and non-16/18 genotypes were identified through L1 gene sequencing and phylogenetic analysis.</p> Results <p>The prevalence of hrHPV infection was 2.23% (8/358). Detected genotypes included HPV16, HPV31, HPV35, HPV45, HPV66, and HPV70. All detected infections were due to high-risk HPV genotypes, of which three were non-vaccine high-risk types. Phylogenetic analysis demonstrated close similarity with globally circulating strains.</p> Conclusions <p>Despite low prevalence, the presence of diverse non-vaccine hrHPV genotypes highlights a potential gap between circulating strains and current vaccine coverage. These findings highlight the importance of continued region-specific HPV surveillance in underserved populations and provide baseline epidemiological data for future studies evaluating cervical cancer prevention strategies.</p>

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Diverse non-vaccine high-risk HPV genotypes in rural Kerala: implications for cervical cancer prevention in an underserved population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月8日

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  • Anusha M. Sharma,
  • Sachin David,
  • Parasmal Suresh,
  • Sivadas Swathi Krishna,
  • Neethu Puthalon Kunnath,
  • Beena Karimbuvayalil Vasudevan,
  • Lalitha Biswas,
  • Keechilat Pavithran

摘要

Background

The distribution of high-risk human papillomavirus (hrHPV) genotypes varies across populations and directly influences cervical cancer prevention strategies. Data from underserved rural populations remain limited.

Methods

A community-based screening study was conducted among 358 women from rural and tribal regions of Kerala, India. High-risk HPV was detected using real-time PCR, and non-16/18 genotypes were identified through L1 gene sequencing and phylogenetic analysis.

Results

The prevalence of hrHPV infection was 2.23% (8/358). Detected genotypes included HPV16, HPV31, HPV35, HPV45, HPV66, and HPV70. All detected infections were due to high-risk HPV genotypes, of which three were non-vaccine high-risk types. Phylogenetic analysis demonstrated close similarity with globally circulating strains.

Conclusions

Despite low prevalence, the presence of diverse non-vaccine hrHPV genotypes highlights a potential gap between circulating strains and current vaccine coverage. These findings highlight the importance of continued region-specific HPV surveillance in underserved populations and provide baseline epidemiological data for future studies evaluating cervical cancer prevention strategies.