Scholarlink

Objective <p>The prognostic role of Epstein-Barr virus (EBV) DNA in aggressive angioimmunoblastic T-cell lymphoma (AITL) remains unclear. This study aimed to investigate the prognostic significance of whole blood EBV DNA at diagnosis in AITL patients, establish an optimal prognostic cutoff, and develop a novel prognostic index incorporating this viral biomarker.</p> Methods <p>This multicenter retrospective study included 323 newly diagnosed AITL patients. The optimal cutoff of EBV DNA was determined using maximally selected rank statistics. Independent prognostic factors identified by multivariate Cox regression were used to construct a novel prognostic index (AITL prognostic index [API]), which was internally validated and compared with existing models.</p> Results <p>At diagnosis, 241 (74.6%) AITL patients were EBV DNA positive, with 143 (44.3%) exceeding the optimal cutoff for EBV DNA load of 6110 copies/mL. EBV DNA &gt; 6110 copies/mL was established as an independent adverse factor for overall survival (HR, 1.553; <i>p</i> =.006), along with age ≥ 60 years, ECOG ≥ 2, platelets &lt; 150 × 10<sup>9</sup>/L, and extranodal sites &gt; 1. Based on these thresholds, API was used to stratify patients into four distinct risk groups with significantly different median OS (<i>p</i> &lt;.001) and demonstrated superior discriminatory power (Harrell’s C-statistic: 0.741; Akaike Information Criterion value: 1829.1) compared to IPI, PIT, PIAI, and AITL score.</p> Conclusions <p>Whole blood EBV DNA load is a powerful, independent prognostic index in AITL. The novel prognostic index API integrates a quantitative EBV DNA cutoff, providing superior risk stratification over established prognostic models, and guideing clinical decision-making for AITL patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prognostic role of whole blood Epstein‑Barr virus DNA load in angioimmunoblastic T-cell lymphoma

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月19日

查看全文
  • Yi Zhong,
  • Mengmeng Dong,
  • Fang Yu,
  • Yi Zhao,
  • Lixia Zhu,
  • Fengping Zhou,
  • Wenjun Wu,
  • Yi Li,
  • Fangshu Guan,
  • Linlin Huang,
  • Xiujin Ye,
  • Zhen Cai,
  • Jin Zhang,
  • Baodong Ye,
  • Qingming Wang,
  • Jingsong He

摘要

Objective

The prognostic role of Epstein-Barr virus (EBV) DNA in aggressive angioimmunoblastic T-cell lymphoma (AITL) remains unclear. This study aimed to investigate the prognostic significance of whole blood EBV DNA at diagnosis in AITL patients, establish an optimal prognostic cutoff, and develop a novel prognostic index incorporating this viral biomarker.

Methods

This multicenter retrospective study included 323 newly diagnosed AITL patients. The optimal cutoff of EBV DNA was determined using maximally selected rank statistics. Independent prognostic factors identified by multivariate Cox regression were used to construct a novel prognostic index (AITL prognostic index [API]), which was internally validated and compared with existing models.

Results

At diagnosis, 241 (74.6%) AITL patients were EBV DNA positive, with 143 (44.3%) exceeding the optimal cutoff for EBV DNA load of 6110 copies/mL. EBV DNA > 6110 copies/mL was established as an independent adverse factor for overall survival (HR, 1.553; p =.006), along with age ≥ 60 years, ECOG ≥ 2, platelets < 150 × 109/L, and extranodal sites > 1. Based on these thresholds, API was used to stratify patients into four distinct risk groups with significantly different median OS (p <.001) and demonstrated superior discriminatory power (Harrell’s C-statistic: 0.741; Akaike Information Criterion value: 1829.1) compared to IPI, PIT, PIAI, and AITL score.

Conclusions

Whole blood EBV DNA load is a powerful, independent prognostic index in AITL. The novel prognostic index API integrates a quantitative EBV DNA cutoff, providing superior risk stratification over established prognostic models, and guideing clinical decision-making for AITL patients.