Scholarlink

Introduction <p>Several systematic reviews have looked at chemotherapy-related toxicities in children with cancer worldwide. In African settings, the rates of ADRs may differ. There is no robust, quantitative estimate of the overall pooled prevalence of chemotherapy-related ADRs among African pediatric oncology patients. Both hematologic and solid tumor patients were included in the analysis. Hence, this study aimed to assess the pooled prevalence of chemotherapy-related adverse drug events among children with all cancer types in Africa.</p> Methods <p>We used a comprehensive search of articles using different databases (7 databases) such as Google Scholar, Cochrane Library, Science Direct, Web of Sciences, Scopus, EMBASE, and PubMed to explore relevant studies. Studies published until November 16, 2025 included in the study. The quality of the included studies was assessed using the Newcastle– Ottawa Quality Assessment Scale. Data was extracted with Microsoft Excel and analyzed using STATA version 17 software. Random effect meta-regression analysis at 95% CI was used to assess the pooled prevalence of chemotherapy-related adverse drug events among children with cancer in Africa. Heterogeneity was determined using the I<sup>2</sup> statistic, and publication bias was evaluated with a funnel plot and Egger test.</p> Result <p>The pooled prevalence of chemotherapy-induced adverse drug events among pediatric cancer patients in Africa from 9 studies revealed that 62.03% (95%CI: 36.93–87.13) and with (I<sup>2</sup> = 99.4, <i>P</i> = 0.000). A Subgroup meta-analysis showed comparatively less heterogeneity in other African countries (I<sup>2</sup> = 88.2%, <i>p</i> = 0.000) as compared to studies conducted in Ethiopia (I<sup>2</sup> = 99%, P-value = 0.000). Moreover, subgroup meta-analysis showed that there was a difference in the strength of heterogeneity between articles published before 2020(I<sup>2</sup> = 99.8%, P-value = 0.000) and after 2020 (I<sup>2</sup> = 97.4%, <i>p</i> = 0.000).</p> Conclusion <p>The burden of chemotherapy-related adverse drug reactions was found to be high. Health care professionals involved in cancer treatment should be prepared to deal with chemotherapy-related adverse drug reactions. Routine ADR surveillance should be integrated into pediatric oncology wards in Africa.</p> Clinical trial number <p>Not applicable.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Systematic review and meta-analysis of chemotherapy-induced adverse drug reactions among children with cancer in Africa

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月24日

查看全文
  • Birbirsa Sefera Senbeta,
  • Tesfaye Negesa Liche,
  • Gemechu Gelana Ararame,
  • Lemi Ushu Sime,
  • Alemayehu Abebe Guji

摘要

Introduction

Several systematic reviews have looked at chemotherapy-related toxicities in children with cancer worldwide. In African settings, the rates of ADRs may differ. There is no robust, quantitative estimate of the overall pooled prevalence of chemotherapy-related ADRs among African pediatric oncology patients. Both hematologic and solid tumor patients were included in the analysis. Hence, this study aimed to assess the pooled prevalence of chemotherapy-related adverse drug events among children with all cancer types in Africa.

Methods

We used a comprehensive search of articles using different databases (7 databases) such as Google Scholar, Cochrane Library, Science Direct, Web of Sciences, Scopus, EMBASE, and PubMed to explore relevant studies. Studies published until November 16, 2025 included in the study. The quality of the included studies was assessed using the Newcastle– Ottawa Quality Assessment Scale. Data was extracted with Microsoft Excel and analyzed using STATA version 17 software. Random effect meta-regression analysis at 95% CI was used to assess the pooled prevalence of chemotherapy-related adverse drug events among children with cancer in Africa. Heterogeneity was determined using the I2 statistic, and publication bias was evaluated with a funnel plot and Egger test.

Result

The pooled prevalence of chemotherapy-induced adverse drug events among pediatric cancer patients in Africa from 9 studies revealed that 62.03% (95%CI: 36.93–87.13) and with (I2 = 99.4, P = 0.000). A Subgroup meta-analysis showed comparatively less heterogeneity in other African countries (I2 = 88.2%, p = 0.000) as compared to studies conducted in Ethiopia (I2 = 99%, P-value = 0.000). Moreover, subgroup meta-analysis showed that there was a difference in the strength of heterogeneity between articles published before 2020(I2 = 99.8%, P-value = 0.000) and after 2020 (I2 = 97.4%, p = 0.000).

Conclusion

The burden of chemotherapy-related adverse drug reactions was found to be high. Health care professionals involved in cancer treatment should be prepared to deal with chemotherapy-related adverse drug reactions. Routine ADR surveillance should be integrated into pediatric oncology wards in Africa.

Clinical trial number

Not applicable.