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HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2024年3月27日

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  • Anna Calliari,
  • Lillian M. Daughrity,
  • Ellen A. Albagli,
  • Paula Castellanos Otero,
  • Mei Yue,
  • Karen Jansen-West,
  • Naeyma N. Islam,
  • Thomas Caulfield,
  • Bailey Rawlinson,
  • Michael DeTure,
  • Casey Cook,
  • Neill R. Graff-Radford,
  • Gregory S. Day,
  • Bradley F. Boeve,
  • David S. Knopman,
  • Ronald C. Petersen,
  • Keith A. Josephs,
  • Björn Oskarsson,
  • Aaron D. Gitler,
  • Dennis W. Dickson,
  • Tania F. Gendron,
  • Mercedes Prudencio,
  • Michael E. Ward,
  • Yong-Jie Zhang,
  • Leonard Petrucelli

摘要

This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.