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Background <p>Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive fibroblast growth factor 23 (FGF23) secretion. However, TIO lesions located in the neurocranium (NC) and intracranial (IC) structures remain poorly characterized.</p> Objective <p>To characterize the clinical features of TIO lesions in NC and IC structures and to compare them with those located in the sinuses.</p> Methods <p>This retrospective study included patients diagnosed with TIO who underwent tumor resection at Peking Union Medical College Hospital between January 2016 and December 2023. Patients with lesions in NC and IC structures were defined as the study group, while those with sinus lesions served as the control group. Clinical characteristics, biochemical parameters, and surgical outcomes were systematically analyzed and compared between groups.</p> Results <p>TIO lesions in NC and IC structures were distributed across the skull base, temporal region, sellar region, frontal lobe, and occipital region. Compared with sinus lesions, patients with NC and IC lesions showed comparable clinical and biochemical profiles but exhibited significantly worse outcomes, including higher rates of non-remission and tumor recurrence. These findings suggest increased difficulty in complete tumor resection and disease control in this subgroup.</p> Conclusion <p>TIO lesions in NC and IC structures are associated with poorer surgical outcomes and higher recurrence rates despite similar baseline characteristics. These results highlight the need for improved localization strategies and tailored management approaches for this challenging subgroup.</p>

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Clinical characteristics of tumor-induced osteomalacia lesions in the neurocranium and intracranial structures

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月7日

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  • Yushuo Wu,
  • Xiang Li,
  • Zhiqin Xu,
  • Wei Lv,
  • Zhixiang Wang,
  • Xiaolin Ni,
  • Qianqian Pang,
  • Ruizhi Jiajue,
  • Yue Chi,
  • Wei Liu,
  • Lijia Cui,
  • Yan Jiang,
  • Ou Wang,
  • Mei Li,
  • Xiaoping Xing,
  • Wenbin Ma,
  • Yu Wang,
  • Yong Yao,
  • Yi Guo,
  • Zhiqiang Gao,
  • Guodong Feng,
  • Fang Qi,
  • Yiyi Gong,
  • Weibo Xia

摘要

Background

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive fibroblast growth factor 23 (FGF23) secretion. However, TIO lesions located in the neurocranium (NC) and intracranial (IC) structures remain poorly characterized.

Objective

To characterize the clinical features of TIO lesions in NC and IC structures and to compare them with those located in the sinuses.

Methods

This retrospective study included patients diagnosed with TIO who underwent tumor resection at Peking Union Medical College Hospital between January 2016 and December 2023. Patients with lesions in NC and IC structures were defined as the study group, while those with sinus lesions served as the control group. Clinical characteristics, biochemical parameters, and surgical outcomes were systematically analyzed and compared between groups.

Results

TIO lesions in NC and IC structures were distributed across the skull base, temporal region, sellar region, frontal lobe, and occipital region. Compared with sinus lesions, patients with NC and IC lesions showed comparable clinical and biochemical profiles but exhibited significantly worse outcomes, including higher rates of non-remission and tumor recurrence. These findings suggest increased difficulty in complete tumor resection and disease control in this subgroup.

Conclusion

TIO lesions in NC and IC structures are associated with poorer surgical outcomes and higher recurrence rates despite similar baseline characteristics. These results highlight the need for improved localization strategies and tailored management approaches for this challenging subgroup.