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Purpose <p>Outcomes of patients with sickle cell disease (SCD) and type 2 diabetes mellitus (T2DM) treated with glucagon-like peptide-1 (GLP1-RA) remain poorly understood. This study evaluated the impact of GLP-1 on adults with SCD and T2DM beyond glycemic control.</p> Methods <p>We conducted a retrospective study within the TriNetX Network, identifying adults with SCD and T2DM. GLP-1 users and non–GLP-1 users were matched using Propensity score matching. The index date was defined as the first GLP-1 prescription, and outcomes were assessed over 12 months. Outcomes were major adverse cardiovascular events (MACE), chronic kidney disease (CKD), vaso-occlusive crises (VOC), and hypoglycemia. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazards models.</p> Results <p>We included 1,391 patients in each cohort, with similar age (48.5 vs. 48.8), and most participants were Black (84.5% vs. 83.8%). GLP-1 therapy was associated with lower risk of MACE (HR 0.61, 95% CI 0.49–0.76; <i>P</i> &lt; 0.00001) and a reduced risk of stroke (HR 0.47, 95% CI 0.23–0.97; <i>P</i> = 0.036). Additionally, GLP-1 use was linked to a 36% lower risk of VOC (HR 0.64, 95% CI 0.45–0.91; <i>P</i> = 0.013). There was no difference in risk of hypoglycemia (HR 1.10, 95% CI 0.60–1.76; <i>P</i> = 0.688) or progression to CKD between the two groups (HR 1.26, 95% CI 0.82–1.95; <i>P</i> = 0.294).</p> Conclusions <p>GLP-1 therapies demonstrate favorable cardioprotective, vaso stabilizing, and safety benefits in adults with SCD and T2DM, supporting their use in this high-risk population.</p> Clinical trial number <p>Not applicable.</p>

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Outcomes of GLP-1 receptor agonist therapy in adults with sickle cell disease and type 2 diabetes: a real-world cohort analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月28日

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  • Guy Loic Nguefang,
  • Sarpong Boateng,
  • Solomon Gyabaah,
  • Yussif Issaka,
  • Joel Gabin Konlack,
  • Edgar Luna Landa,
  • Elvis Eze,
  • Basile Njei

摘要

Purpose

Outcomes of patients with sickle cell disease (SCD) and type 2 diabetes mellitus (T2DM) treated with glucagon-like peptide-1 (GLP1-RA) remain poorly understood. This study evaluated the impact of GLP-1 on adults with SCD and T2DM beyond glycemic control.

Methods

We conducted a retrospective study within the TriNetX Network, identifying adults with SCD and T2DM. GLP-1 users and non–GLP-1 users were matched using Propensity score matching. The index date was defined as the first GLP-1 prescription, and outcomes were assessed over 12 months. Outcomes were major adverse cardiovascular events (MACE), chronic kidney disease (CKD), vaso-occlusive crises (VOC), and hypoglycemia. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazards models.

Results

We included 1,391 patients in each cohort, with similar age (48.5 vs. 48.8), and most participants were Black (84.5% vs. 83.8%). GLP-1 therapy was associated with lower risk of MACE (HR 0.61, 95% CI 0.49–0.76; P < 0.00001) and a reduced risk of stroke (HR 0.47, 95% CI 0.23–0.97; P = 0.036). Additionally, GLP-1 use was linked to a 36% lower risk of VOC (HR 0.64, 95% CI 0.45–0.91; P = 0.013). There was no difference in risk of hypoglycemia (HR 1.10, 95% CI 0.60–1.76; P = 0.688) or progression to CKD between the two groups (HR 1.26, 95% CI 0.82–1.95; P = 0.294).

Conclusions

GLP-1 therapies demonstrate favorable cardioprotective, vaso stabilizing, and safety benefits in adults with SCD and T2DM, supporting their use in this high-risk population.

Clinical trial number

Not applicable.