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Background <p>Peripheral odontogenic keratocyst (POKC) is a rare extraosseous manifestation of odontogenic keratocyst (OKC). Because of their anatomical locations, OKCs and POKCs necessitate slightly different treatment approaches. However, the reported literature has not yet reached a definitive conclusion on this matter.</p> Methods <p>This study included 2 patients who experienced postoperative recurrence of POKCs in the right buccal mucosa from 2018 to 2020. Additionally, we reviewed the reported cases and summarized the clinical features, treatment and prognosis of the POKCs.</p> Results <p>The two patients with POKCs in this report experienced recurrence after the first surgery, and the second operation involved microscopic excision of the lesion with its adherent tissue. No recurrence was observed.</p> Conclusions <p>Because POKCs are located in the soft tissue, they are difficult to remove and therefore prone to recur. In the treatment of POKCs, the surrounding adhesions can also be removed. Microscopic excision should be performed as well.</p>

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Clinical manifestations and treatment of peripheral odontogenic keratocysts: two cases and a literature review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月30日

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  • Yu Huang,
  • Lirui Zhang,
  • Xiaohong Yuan,
  • Zhien Feng

摘要

Background

Peripheral odontogenic keratocyst (POKC) is a rare extraosseous manifestation of odontogenic keratocyst (OKC). Because of their anatomical locations, OKCs and POKCs necessitate slightly different treatment approaches. However, the reported literature has not yet reached a definitive conclusion on this matter.

Methods

This study included 2 patients who experienced postoperative recurrence of POKCs in the right buccal mucosa from 2018 to 2020. Additionally, we reviewed the reported cases and summarized the clinical features, treatment and prognosis of the POKCs.

Results

The two patients with POKCs in this report experienced recurrence after the first surgery, and the second operation involved microscopic excision of the lesion with its adherent tissue. No recurrence was observed.

Conclusions

Because POKCs are located in the soft tissue, they are difficult to remove and therefore prone to recur. In the treatment of POKCs, the surrounding adhesions can also be removed. Microscopic excision should be performed as well.