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Background <p>SATB2-associated syndrome (SAS) results from various mutations of the <i>SATB2</i> gene and associates a neurodevelopmental disorder including major speech delay, intellectual disability, and behavioral problems with dental anomalies, sometimes a cleft palate, risk of osteoporosis, and facial dysmorphism. The principal objective of this study was to describe the oral phenotype of young children with SATB2-associated syndrome, especially in terms of orofacial malformation of Robin Sequence (RS) spectrum (bifid uvula, cleft palate, or&#xa0;RS, dental malformation, feeding and communication, with data from a national cohort. The secondary objective was to determine whether feeding and communication disorders were more severe when associated with an orofacial malformation of RS spectrum.</p> Methods <p>We conducted a retrospective cross-sectional study among the largest possible cohort of patients with a mutation of the <i>SATB2</i> gene in France. A questionnaire completed by the referring physicians and by telephone with parents enabled us to collect the following clinical information: (1) orofacial morphology, feeding difficulties, and pharyngeal functioning from birth to 3&#xa0;years, (2) communication and language from 0 to 6&#xa0;years, (3) speech development at the last examination.</p> Results <p>The study included 40 patients. Early and persistent feeding difficulties were found in 55% of the children. Communication was abnormal from the first months of life, with poor babbling in 85% of them. A major language delay was described in all patients; 65% had a vocabulary of 10 words or less. An anomaly of RS spectrum was found in half the cases, and dental malformations were described in 90%. Feeding difficulties and language delay were greater in the group with one or more orofacial malformations than the group with none.</p> Conclusion <p>This study confirmed the severity of oral involvement, affecting feeding and speech simultaneously, in individuals with SAS. It raises the question of why the oral phenotype involving feeding and speech is more severe in the presence of cleft palate or RS. We recommend close monitoring of prelanguage communication in infants with apparently isolated cleft palate or RS and the search for <i>SATB2</i> impairment when a cleft palate or RS is found, especially in the prenatal period.</p>

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Oral phenotype in SATB2-associated syndrome: cross-sectional study of the French cohort

  • 期刊论文

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  • 发表日期：

    2025年6月5日

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  • Nancy Vegas,
  • Marlène Rio,
  • Pauline Adnot,
  • Véronique Soupre,
  • Florence Petit,
  • Jamal Ghoumid,
  • Annick Toutain,
  • Klaus Dieterich,
  • Isabelle Marey,
  • Brigitte Gilbert-Dussardier,
  • Gwenaël Le Guyader,
  • Christine Francannet,
  • Elise Schaefer,
  • Laurence Perrin,
  • Mathilde Nizon,
  • Claire Beneteau,
  • David Genevieve,
  • Marjolaine Willems,
  • Laurence Faivre,
  • Marianne Grimaldi,
  • Judith Melki,
  • Radka Stoeva,
  • Audrey Putoux,
  • Linda Pons,
  • Karelle Benistan,
  • Jeanne Amiel,
  • Véronique Abadie

摘要

Background

SATB2-associated syndrome (SAS) results from various mutations of the SATB2 gene and associates a neurodevelopmental disorder including major speech delay, intellectual disability, and behavioral problems with dental anomalies, sometimes a cleft palate, risk of osteoporosis, and facial dysmorphism. The principal objective of this study was to describe the oral phenotype of young children with SATB2-associated syndrome, especially in terms of orofacial malformation of Robin Sequence (RS) spectrum (bifid uvula, cleft palate, or RS, dental malformation, feeding and communication, with data from a national cohort. The secondary objective was to determine whether feeding and communication disorders were more severe when associated with an orofacial malformation of RS spectrum.

Methods

We conducted a retrospective cross-sectional study among the largest possible cohort of patients with a mutation of the SATB2 gene in France. A questionnaire completed by the referring physicians and by telephone with parents enabled us to collect the following clinical information: (1) orofacial morphology, feeding difficulties, and pharyngeal functioning from birth to 3 years, (2) communication and language from 0 to 6 years, (3) speech development at the last examination.

Results

The study included 40 patients. Early and persistent feeding difficulties were found in 55% of the children. Communication was abnormal from the first months of life, with poor babbling in 85% of them. A major language delay was described in all patients; 65% had a vocabulary of 10 words or less. An anomaly of RS spectrum was found in half the cases, and dental malformations were described in 90%. Feeding difficulties and language delay were greater in the group with one or more orofacial malformations than the group with none.

Conclusion

This study confirmed the severity of oral involvement, affecting feeding and speech simultaneously, in individuals with SAS. It raises the question of why the oral phenotype involving feeding and speech is more severe in the presence of cleft palate or RS. We recommend close monitoring of prelanguage communication in infants with apparently isolated cleft palate or RS and the search for SATB2 impairment when a cleft palate or RS is found, especially in the prenatal period.