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<p>Diabetic kidney disease (DKD) is a severe complication of diabetes and a leading cause of end-stage renal disease (ESRD). It is characterized by a complex pathogenesis that involves genetic, epigenetic, metabolic, and multifactorial elements. Current therapeutic approaches for DKD have significant limitations. In contrast, Traditional Chinese Medicine (TCM), with its personalized treatment based on syndrome differentiation, shows potential to modulate multiple pathological pathways implicated in DKD. This review provides a detailed examination of DKD pathogenesis and the progress in TCM research, offering valuable insights for DKD treatment research and clinical practice.</p>

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Traditional Chinese medicine in diabetic kidney disease: multifaceted therapeutic mechanisms and research progress

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月1日

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  • Rushuang Cai,
  • Chunying Li,
  • Yong Zhao,
  • Haisheng Yuan,
  • Xiaomeng Zhang,
  • Aihua Liang,
  • Yan Yi

摘要

Diabetic kidney disease (DKD) is a severe complication of diabetes and a leading cause of end-stage renal disease (ESRD). It is characterized by a complex pathogenesis that involves genetic, epigenetic, metabolic, and multifactorial elements. Current therapeutic approaches for DKD have significant limitations. In contrast, Traditional Chinese Medicine (TCM), with its personalized treatment based on syndrome differentiation, shows potential to modulate multiple pathological pathways implicated in DKD. This review provides a detailed examination of DKD pathogenesis and the progress in TCM research, offering valuable insights for DKD treatment research and clinical practice.