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Objective <p>Comparison of the efficacy of the oXiris filter and the ST-100 filter in patients with postoperative cardiac surgery infections combined with acute kidney injury.</p> Methods <p>This is a retrospective cohort study of patients with postoperative cardiac surgical infections combined with acute kidney injury who underwent continuous renal replacement therapy from January 2023 to April 2024 in the Critical Care Medicine Centre of the First Affiliated Hospital of Xinjiang Medical University. Based on the application of different filters, they were divided into the oXiris group and the ST-100 group, and the general condition, clinical data and related indexes of the two groups were collected at baseline (T0), 10&#xa0;h after treatment (T1), 24&#xa0;h after treatment (T2) and 48&#xa0;h after treatment (T3), respectively, to compare the treatment effect, length of hospital stay and outcome events of the two groups at T1, T2 and T3, to explore the different therapeutic values of oXiris filter and ST-100 filter.</p> Results <p>A total of 33 patients were included, 11 (<i>n</i> = 11) in the oXiris group and 22 (<i>n</i> = 22) in the ST group.Intra-group comparisons between the two groups: of norepinephrine dose (F<sub>Intra-group</sub>=6.799, <i>P</i> &lt; 0.05), VIS (F<sub>Intra-group</sub>=5.919, <i>P</i> &lt; 0.05) and MAP (F<sub>Intra-group</sub>=6.387, <i>P</i> &lt; 0.05), with a time trend.IL-6 (F<sub>Intra-group</sub>=3.262, <i>P</i> &lt; 0.05) had a time-varying trend with a significant decrease.Comparison between the two groups: there was a significant difference in the magnitude of change in MAP (F<sub>Intergroup</sub>=8.347, <i>P</i> &lt; 0.05) and IL-6 (F<sub>Intergroup</sub>= 6.779, <i>P</i> &lt; 0.05).The magnitude of change in IL-6 was seen to be significantly better in the oXiris group than in the ST-100 group at the T0-1 time period (<i>P</i> = 0.003).Plotting the survival curve the overall survival rate was higher in the oXiris group than in the ST-100 group, and the Log-Rank test did not show a significant difference between the two groups (<i>P</i> = 0.311).</p> Conclusion <p>This study indicates the oXiris filter effectively removes inflammatory mediators in patients with postoperative infections and acute kidney injury(characteristically manifested in the first 10&#xa0;h), compared to the ST-100 filter. It also aids hemodynamic stability and reduces vasopressor doses, but shows no statistical improvement in organ function or patient prognosis.</p>

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Comparison of the efficacy of the oXiris filter and the ST-100 filter in patients with postoperative cardiac surgery infections combined with acute kidney injury: a retrospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月16日

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  • Rui Wang,
  • Yucheng Ren,
  • Yunlin Song,
  • Ying Li,
  • Bingyu Ma,
  • Yaowei Tong,
  • Wangtao Zhou

摘要

Objective

Comparison of the efficacy of the oXiris filter and the ST-100 filter in patients with postoperative cardiac surgery infections combined with acute kidney injury.

Methods

This is a retrospective cohort study of patients with postoperative cardiac surgical infections combined with acute kidney injury who underwent continuous renal replacement therapy from January 2023 to April 2024 in the Critical Care Medicine Centre of the First Affiliated Hospital of Xinjiang Medical University. Based on the application of different filters, they were divided into the oXiris group and the ST-100 group, and the general condition, clinical data and related indexes of the two groups were collected at baseline (T0), 10 h after treatment (T1), 24 h after treatment (T2) and 48 h after treatment (T3), respectively, to compare the treatment effect, length of hospital stay and outcome events of the two groups at T1, T2 and T3, to explore the different therapeutic values of oXiris filter and ST-100 filter.

Results

A total of 33 patients were included, 11 (n = 11) in the oXiris group and 22 (n = 22) in the ST group.Intra-group comparisons between the two groups: of norepinephrine dose (FIntra-group=6.799, P < 0.05), VIS (FIntra-group=5.919, P < 0.05) and MAP (FIntra-group=6.387, P < 0.05), with a time trend.IL-6 (FIntra-group=3.262, P < 0.05) had a time-varying trend with a significant decrease.Comparison between the two groups: there was a significant difference in the magnitude of change in MAP (FIntergroup=8.347, P < 0.05) and IL-6 (FIntergroup= 6.779, P < 0.05).The magnitude of change in IL-6 was seen to be significantly better in the oXiris group than in the ST-100 group at the T0-1 time period (P = 0.003).Plotting the survival curve the overall survival rate was higher in the oXiris group than in the ST-100 group, and the Log-Rank test did not show a significant difference between the two groups (P = 0.311).

Conclusion

This study indicates the oXiris filter effectively removes inflammatory mediators in patients with postoperative infections and acute kidney injury(characteristically manifested in the first 10 h), compared to the ST-100 filter. It also aids hemodynamic stability and reduces vasopressor doses, but shows no statistical improvement in organ function or patient prognosis.