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Purpose <p>A 31-year-old female patient presented with a giant primary cardiac malignancy occupying the right atrium and invading the tricuspid valve and right ventricle.</p> Methods <p>Due to the inoperability of the tumor by conventional surgery, heart transplantation was considered. However, the patient had a strongly positive panel reactive antibody (PRA), indicating a high risk of rejection. Our team performed an emergency heart transplantation and administered a combination of immunosuppressive therapies postoperatively.</p> Result <p>One month after the transplantation, the patient recovered smoothly and was discharged from the hospital.</p> Conclusion <p>Despite giant cardiac sarcoma and high PRA-mediated rejection risk, tailored perioperative strategies, including aggressive desensitization, multimodal immunosuppression, and close surveillance, enabled successful transplantation and recovery. This highlights the feasibility of heart transplantation in select sarcoma cases with meticulous rejection management.</p>

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A rare case of giant cardiac malignant tumor with positive panel reactive antibody

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月23日

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  • Xing Chen,
  • Yuqing Zhang,
  • Wenjun Yu,
  • Wei Wang,
  • Jie Cai,
  • Jinping Liu

摘要

Purpose

A 31-year-old female patient presented with a giant primary cardiac malignancy occupying the right atrium and invading the tricuspid valve and right ventricle.

Methods

Due to the inoperability of the tumor by conventional surgery, heart transplantation was considered. However, the patient had a strongly positive panel reactive antibody (PRA), indicating a high risk of rejection. Our team performed an emergency heart transplantation and administered a combination of immunosuppressive therapies postoperatively.

Result

One month after the transplantation, the patient recovered smoothly and was discharged from the hospital.

Conclusion

Despite giant cardiac sarcoma and high PRA-mediated rejection risk, tailored perioperative strategies, including aggressive desensitization, multimodal immunosuppression, and close surveillance, enabled successful transplantation and recovery. This highlights the feasibility of heart transplantation in select sarcoma cases with meticulous rejection management.