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Background <p>Bronchus and lung cancer are one of the most common and deadly types of cancer in the United States. This study analyzed the mortality trends related to bronchus and lung cancer among U.S. adults ≥ 25 years old from 1999 to 2023 from demographic and geographic perspectives.</p> Methods <p>We utilized the CDC WONDER database to investigate the trends in Bronchus and lung cancer-related mortality in the United States. Age-adjusted mortality rates per 100,000 people (AAMR), annual percentage change (APC), and average annual percentage change (AAPC) with 95% confidence intervals (CIs) were calculated, and the data were stratified by year, age groups, sex, race/ethnicity, census region, urban–rural, and states classification. The Joinpoint Regression Program was utilized to estimate mortality trends between 1999 and 2023.</p> Results <p>From 1999 to 2023, 3 778 040 bronchus and lung-cancer deaths were recorded. The AAMRs fell from 55.41 per 100 000 (95% CI: 55.14 to 55.69) in 1999 to 29.49 (95% CI: 29.33 to 29.65) in 2023, yielding an average AAPC of -2.63% (95% CI: -2.92 to -2.34; p &lt; 0.001). Crude mortality rates decreased in every age group; The 25–34 age group maintained the lowest CMRs, and decreased modestly (AAPC: -2.515, 95% CI: -3.07 to -1.96). Males exhibited higher AAMRs than females, but their decline was steeper (male AAPC: -3.35%; 95% CI: -3.68 to -3.01 vs female -1.85%; 95% CI: -2.09 to -1.61; both p &lt; 0.001). Non-Hispanic Black individuals had the highest AAMRs consistently but recorded the fastest decrease (AAPC -3.05%; 95% CI: -3.26 to -2.83; p &lt; 0.001), while Hispanic or Latino individuals had the lowest (AAMR 2023: 20.21; 95% CI: 19.67 to 20.75). Geographically, the West had the lowest AAMR and the sharpest decline (AAPC: -3.21%; 95% CI: -3.57 to -2.84; p &lt; 0.001). Metropolitan areas improved faster than non-metropolitan areas (AAPC: -2.83% vs -1.73%; both p &lt; 0.001). By state, the largest 1999 to 2023 reductions were observed in the District of Columbia (-59%), Nevada (-57%), and California (-56%), whereas Kentucky remained the highest in 2023 (AAMR: 75.62; 95% CI: 74.28 to 76.96). A minor rebound in 2020–2023 (APC: -3.02%; 95% CI: -3.79 to -2.24; p = 0.004) coincided with the COVID-19 period.</p> Conclusion <p>It is crucial to assess potential health disparities among different regions and population groups. There is an urgent need for further research and the implementation of targeted public health interventions, as well as improvements in resource allocation and health outcomes among populations.</p>

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Bronchus and lung cancer-related mortality trends in the United States from 1999 to 2023

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  • 发表日期：

    2026年4月16日

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  • Mingfeng Wei,
  • Yun Wu,
  • Zheng Li,
  • Xiaoyu Chen,
  • Xuelin Zhang,
  • Fuzhi Yang,
  • Shuai Jiang,
  • Lefei Hu,
  • Shixiang Guo,
  • Xunxia Zhu,
  • Xiaoyong Shen

摘要

Background

Bronchus and lung cancer are one of the most common and deadly types of cancer in the United States. This study analyzed the mortality trends related to bronchus and lung cancer among U.S. adults ≥ 25 years old from 1999 to 2023 from demographic and geographic perspectives.

Methods

We utilized the CDC WONDER database to investigate the trends in Bronchus and lung cancer-related mortality in the United States. Age-adjusted mortality rates per 100,000 people (AAMR), annual percentage change (APC), and average annual percentage change (AAPC) with 95% confidence intervals (CIs) were calculated, and the data were stratified by year, age groups, sex, race/ethnicity, census region, urban–rural, and states classification. The Joinpoint Regression Program was utilized to estimate mortality trends between 1999 and 2023.

Results

From 1999 to 2023, 3 778 040 bronchus and lung-cancer deaths were recorded. The AAMRs fell from 55.41 per 100 000 (95% CI: 55.14 to 55.69) in 1999 to 29.49 (95% CI: 29.33 to 29.65) in 2023, yielding an average AAPC of -2.63% (95% CI: -2.92 to -2.34; p < 0.001). Crude mortality rates decreased in every age group; The 25–34 age group maintained the lowest CMRs, and decreased modestly (AAPC: -2.515, 95% CI: -3.07 to -1.96). Males exhibited higher AAMRs than females, but their decline was steeper (male AAPC: -3.35%; 95% CI: -3.68 to -3.01 vs female -1.85%; 95% CI: -2.09 to -1.61; both p < 0.001). Non-Hispanic Black individuals had the highest AAMRs consistently but recorded the fastest decrease (AAPC -3.05%; 95% CI: -3.26 to -2.83; p < 0.001), while Hispanic or Latino individuals had the lowest (AAMR 2023: 20.21; 95% CI: 19.67 to 20.75). Geographically, the West had the lowest AAMR and the sharpest decline (AAPC: -3.21%; 95% CI: -3.57 to -2.84; p < 0.001). Metropolitan areas improved faster than non-metropolitan areas (AAPC: -2.83% vs -1.73%; both p < 0.001). By state, the largest 1999 to 2023 reductions were observed in the District of Columbia (-59%), Nevada (-57%), and California (-56%), whereas Kentucky remained the highest in 2023 (AAMR: 75.62; 95% CI: 74.28 to 76.96). A minor rebound in 2020–2023 (APC: -3.02%; 95% CI: -3.79 to -2.24; p = 0.004) coincided with the COVID-19 period.

Conclusion

It is crucial to assess potential health disparities among different regions and population groups. There is an urgent need for further research and the implementation of targeted public health interventions, as well as improvements in resource allocation and health outcomes among populations.