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Purpose <p>The prognostic value of the Naples prognostic score in lung cancer remains controversial. Therefore, we performed a meta-analysis of relevant published studies to determine the prognostic value of the Naples prognostic score in patients with lung cancer.</p> Methods <p>We conducted a systematic search of relevant studies in PubMed, Ovid, the Cochrane Library, and Web of Science databases. Data and characteristics of each study were extracted and hazard ratios (HRs) at 95% confidence intervals (95% CI) were calculated to estimate effects. A meta-regression analysis was used to assess the prognostic value of the Naples Prognostic Score in patients with lung cancer.</p> Results <p>A total of 1691 patients from six studies were included in this meta-analysis, with a combined HR of 3.357 (95% CI: 1.964–5.738, P &lt; 0.001); the results suggest that a high Naples Prognostic Score predicts a shorter overall survival (OS) for patients.</p> Conclusion <p>This meta-analysis suggests that a high Naples Prognostic Score may be a predictor of poor prognosis in lung cancer patients. Further large cohort studies are needed to confirm these findings.</p>

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Prognostic role of Naples Prognostic Score in lung cancer: a meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月12日

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  • Shicheng Liu,
  • Hongzhen Zhao,
  • Zhaohui Han,
  • Dahu Ren,
  • Zengming Wang,
  • Chunyan Zhao,
  • Xiaopeng Zhang,
  • Qingtao Zhao,
  • Guochen Duan

摘要

Purpose

The prognostic value of the Naples prognostic score in lung cancer remains controversial. Therefore, we performed a meta-analysis of relevant published studies to determine the prognostic value of the Naples prognostic score in patients with lung cancer.

Methods

We conducted a systematic search of relevant studies in PubMed, Ovid, the Cochrane Library, and Web of Science databases. Data and characteristics of each study were extracted and hazard ratios (HRs) at 95% confidence intervals (95% CI) were calculated to estimate effects. A meta-regression analysis was used to assess the prognostic value of the Naples Prognostic Score in patients with lung cancer.

Results

A total of 1691 patients from six studies were included in this meta-analysis, with a combined HR of 3.357 (95% CI: 1.964–5.738, P < 0.001); the results suggest that a high Naples Prognostic Score predicts a shorter overall survival (OS) for patients.

Conclusion

This meta-analysis suggests that a high Naples Prognostic Score may be a predictor of poor prognosis in lung cancer patients. Further large cohort studies are needed to confirm these findings.