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Background <p>Extracorporeal cardiopulmonary resuscitation (eCPR) is a new approach for cardiac arrest management and is regarded as a possible alternative for conventional cardiopulmonary resuscitation (cCPR).</p> Aim <p>Our systematic review and meta-analysis seek to compare outcomes of cCPR versus eCPR in patients with out-of-hospital cardiac arrest (OHCA).</p> Methods <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in this study and the questionnaire utilized the PICO (Patient, Intervention, Control, Outcome) framework. A search strategy using MeSH (Medical Subject Headings) terms was made from which Pubmed/Medline, SCOPUS, and Cochrane Library were searched from inception till March 2024 to reveal all relevant studies. Conference proceedings, <a href="http://www.clinicaltrials.gov">www.clinicaltrials.gov</a>, and bibliometrics of published articles were also searched for gray literature.</p> Results <p>Compared with conventional CPR (cCPR), extracorporeal CPR (eCPR) was associated with higher odds of favorable neurological outcome at discharge (OR 2.61, 95% CI 1.28–5.32; <i>p</i> = 0.008; I²=82%), 3-months (OR 3.29, 95% CI 1.63–6.63; <i>p</i> = 0.0009; I²=46%), and 6-months (OR 1.97, 95% CI 1.24–3.12; <i>p</i> = 0.004; I²=12%). The increase at 1-month was not significant (OR 2.15, 95% CI 0.87–5.34; <i>p</i> = 0.10; I²=90%). eCPR also improved survival-to-discharge (OR 1.84, 95% CI 1.17–2.92; <i>p</i> = 0.009; I²=73%).</p> Conclusion <p>eCPR in the management of OHCA patients has more favorable neurological and survival outcomes as compared to cCPR.</p>

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Extra-corporeal-cardiopulmonary-resuscitation vs. conventional-cardiopulmonary-resuscitation: an in-depth look into short- and long-term neurological outcomes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月24日

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  • Farah Yasmin,
  • Asad Ur Rab,
  • Afia Salman,
  • Muhammad Ahmed Ali Fahim,
  • Hafsah Alim Ur Rahman,
  • Abdul Moeed,
  • Eman Ali,
  • Muhammad Sohaib Asghar,
  • Iqbal Ratnani,
  • Salim Surani

摘要

Background

Extracorporeal cardiopulmonary resuscitation (eCPR) is a new approach for cardiac arrest management and is regarded as a possible alternative for conventional cardiopulmonary resuscitation (cCPR).

Aim

Our systematic review and meta-analysis seek to compare outcomes of cCPR versus eCPR in patients with out-of-hospital cardiac arrest (OHCA).

Methods

Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in this study and the questionnaire utilized the PICO (Patient, Intervention, Control, Outcome) framework. A search strategy using MeSH (Medical Subject Headings) terms was made from which Pubmed/Medline, SCOPUS, and Cochrane Library were searched from inception till March 2024 to reveal all relevant studies. Conference proceedings, www.clinicaltrials.gov, and bibliometrics of published articles were also searched for gray literature.

Results

Compared with conventional CPR (cCPR), extracorporeal CPR (eCPR) was associated with higher odds of favorable neurological outcome at discharge (OR 2.61, 95% CI 1.28–5.32; p = 0.008; I²=82%), 3-months (OR 3.29, 95% CI 1.63–6.63; p = 0.0009; I²=46%), and 6-months (OR 1.97, 95% CI 1.24–3.12; p = 0.004; I²=12%). The increase at 1-month was not significant (OR 2.15, 95% CI 0.87–5.34; p = 0.10; I²=90%). eCPR also improved survival-to-discharge (OR 1.84, 95% CI 1.17–2.92; p = 0.009; I²=73%).

Conclusion

eCPR in the management of OHCA patients has more favorable neurological and survival outcomes as compared to cCPR.