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Background <p>Eosinophilic adenoma, a benign tumor characterized by eosinophilic cell proliferation, typically arises in endocrine organs such as the thyroid or parathyroid glands. Ectopic parathyroid eosinophilic adenoma is rare and may mimic other mediastinal pathologies, leading to diagnostic challenges.</p> Case presentation <p>We present a case of a 54-year-old woman with a one-year history of dysphagia. Initial imaging and endoscopic studies suggested an esophageal stromal tumor. Thoracoscopic resection revealed a posterior mediastinal mass, later confirmed as an ectopic parathyroid eosinophilic adenoma through histopathological and immunohistochemical analysis.</p> Conclusions <p>This case underscores the importance of integrating imaging, laboratory tests, and histopathology for accurate diagnosis of mediastinal masses. Minimally invasive thoracoscopic surgery proved effective for resection, highlighting the need for tailored therapeutic approaches. In order to avoid such misdiagnosis, clinicians should make a definite pathological diagnosis before surgery as much as possible.</p>

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A mediastinal eosinophilic adenoma misdiagnosed as an esophageal stromal tumor: A case report

  • 期刊论文

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  • 发表日期：

    2025年10月31日

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  • Siyu Chen,
  • Jusi Wang,
  • Ning Ao,
  • Shouyin Di,
  • Hui Wu,
  • Taiqian Gong

摘要

Background

Eosinophilic adenoma, a benign tumor characterized by eosinophilic cell proliferation, typically arises in endocrine organs such as the thyroid or parathyroid glands. Ectopic parathyroid eosinophilic adenoma is rare and may mimic other mediastinal pathologies, leading to diagnostic challenges.

Case presentation

We present a case of a 54-year-old woman with a one-year history of dysphagia. Initial imaging and endoscopic studies suggested an esophageal stromal tumor. Thoracoscopic resection revealed a posterior mediastinal mass, later confirmed as an ectopic parathyroid eosinophilic adenoma through histopathological and immunohistochemical analysis.

Conclusions

This case underscores the importance of integrating imaging, laboratory tests, and histopathology for accurate diagnosis of mediastinal masses. Minimally invasive thoracoscopic surgery proved effective for resection, highlighting the need for tailored therapeutic approaches. In order to avoid such misdiagnosis, clinicians should make a definite pathological diagnosis before surgery as much as possible.