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Background and aims <p>This study aimed to evaluate RBM15 gene expression and the potential effects as a biomarker in LUAD progression.</p> Materials and methods <p>The RNA sequencing (RNA-seq) data and clinical data of patients with LUAD were acquired from The Cancer Genome Atlas (TCGA) databases. Kaplan-Meier (K-M) curves were generated to investigate the relationship between RBM15 and the prognosis of patients with LUAD. Gene Ontology (GO) and Reactome enrichment analyses were performed using the “cluster Profiler” R package. Finally, the Tumor Immune Estimation Resource (TIMER)database and CIBERSORT algorithm were used to assess the correlations between RBM15 expression and immune infiltration in LUAD.</p> Results <p>RBM15 was upregulated in tumor tissue, and it was regarded as an independent prognostic factor in LUAD. The genes co-expressed with RBM15 were closely related to cell cycle checkpoints and M phase signaling pathways. Furthermore, there was a significant correlation between RBM15 gene expression and immune infiltration in LUAD.</p> Conclusion <p>Our data suggested that RBM15 is critical in LUAD progression, is associated with tumor immune infiltration and served as a valuable potential diagnostic biomarker in patients.</p>

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RBM15 is a novel prognostic biomarker and correlates with immune cell infiltration in lung adenocarcinoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月24日

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  • Mingsheng Ma,
  • Wei Wang,
  • Li Li,
  • Xiaoyan Wang,
  • Qiubo Huang,
  • Chen Zhou,
  • Lianhua Ye

摘要

Background and aims

This study aimed to evaluate RBM15 gene expression and the potential effects as a biomarker in LUAD progression.

Materials and methods

The RNA sequencing (RNA-seq) data and clinical data of patients with LUAD were acquired from The Cancer Genome Atlas (TCGA) databases. Kaplan-Meier (K-M) curves were generated to investigate the relationship between RBM15 and the prognosis of patients with LUAD. Gene Ontology (GO) and Reactome enrichment analyses were performed using the “cluster Profiler” R package. Finally, the Tumor Immune Estimation Resource (TIMER)database and CIBERSORT algorithm were used to assess the correlations between RBM15 expression and immune infiltration in LUAD.

Results

RBM15 was upregulated in tumor tissue, and it was regarded as an independent prognostic factor in LUAD. The genes co-expressed with RBM15 were closely related to cell cycle checkpoints and M phase signaling pathways. Furthermore, there was a significant correlation between RBM15 gene expression and immune infiltration in LUAD.

Conclusion

Our data suggested that RBM15 is critical in LUAD progression, is associated with tumor immune infiltration and served as a valuable potential diagnostic biomarker in patients.