A randomized study on the impact of optimized modified ultrafiltration on the physiological parameters of infants and children undergoing a cardiopulmonary bypass

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2024年12月20日

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Jianhong Niu,
Guangdi Zhai,
Wei Zhang,
Juanying Zhou,
Shengqi Jiang,
Jianping Ma,
Aibin Zheng

摘要

Background

The aim of this study is to assess the impact of optimized modified ultrafiltration (OMUF) on the physiological parameters of infants and children undergoing cardiopulmonary bypass (CPB).

Methods

In this randomized clinical trial, 30 pediatric patients were recruited and allocated into the experimental and control groups, each comprising of 15 patients. The experimental group underwent OMUF prior to the termination of CPB and extubation, while the control group received conventional modified ultrafiltration (MUF).

Results

In the experimental group, post-ultrafiltration levels of Na+, Ca++, hemoglobin (Hb), and hematocrit (HCT) exhibited a statistically significant increase compared to pre-ultrafiltration levels (p < 0.05), whereas no statistically significant differences were observed in the control group.

Conclusion

The optimization of conventional MUF led to a significant enhancement in ultrafiltration efficacy, thereby exerting a beneficial impact on improving the physiological parameters of pediatric patients during CPB, surpassing conventional practices.