Effective Apixaban removal using hemoadsorption during emergent open-heart surgery: a case report and narrative literature review

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2024年4月6日

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Vitor Mendes,
Jaid Mamode,
Jalal Jolou,
Mourad Malki,
Christoph Ellenberger,
Mustafa Cikirikcioglu,
Christoph Huber

摘要

Background

The management of hemostasis in patients medicated with apixaban (Eliquis) undergoing emergency cardiac surgery is exceedingly difficult. The body’s natural elimination pathways for apixaban prove ineffective in emergency situations, and the impact of hemodialysis is limited. The application of Cytosorb^® may attenuate the concentration of apixaban, thereby facilitating the stabilization of these patients.

Case presentation

An 84-year-old man treated with apixaban, underwent emergency ascending aorta replacement surgery due to an acute type A aortic dissection. To address the challenges induced by apixaban, we integrated Cytosorb^® cartridge into the Cardiopulmonary bypass circuit. There was a 63.7% decrease in perioperative apixaban-specific anti-factor Xa activity. The patient’s postoperative course was favourable.

Conclusion

Hemoadsorption with Cytosorb^® may offers a safe and feasible approach for reducing apixaban concentration in emergency cardiac surgery, thereby mitigating the risk of hemorrhagic complications.