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Background and objective <p>Osteosarcopenia, a comorbidity of osteoporosis and sarcopenia in the elderly, involves bone-muscle crosstalk, but its core molecular mechanism remains unclear. miR-206 is traditionally considered muscle-specific; this study explores miR-206-3p’s expression in musculoskeletal tissue and correlation with clinical parameters.</p> Methods <p>A prospective cohort of 158 elderly hip fracture patients (79 osteosarcopenia, 79 controls) was enrolled. qRT-PCR, in situ hybridization, and scRNA-seq were used to analyze miR-206-3p’s expression, distribution, and cell specificity. Correlations with grip strength, gait speed, and BMD were assessed.</p> Results <p>miR-206-3p was significantly downregulated in both tissues of the osteosarcopenia group (P &lt; 0.001), highly expressed in Myod1⁺ muscle satellite cells and Runx2⁺ osteoprogenitor cells (&gt; 82%), and weakly in mature cells (&lt; 12%). It positively correlated with grip strength, gait speed, and BMD (r = 0.562–0.682, P &lt; 0.001).</p> Conclusion <p>miR-206-3p is co-expressed in bone-muscle progenitor cells, with synchronous downregulation linked to functional decline, challenging its "muscle-specific" notion and serving as a key molecular hub for bone-muscle crosstalk.</p>

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The expression characteristics of miR-206-3p in musculoskeletal tissue and its clinical significance

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月25日

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  • Khan Akhtar Ali,
  • Xuefeng Yuan,
  • Tianxiang Cui,
  • Qianqian Yu,
  • Zhiqian Yi,
  • Hui Huang

摘要

Background and objective

Osteosarcopenia, a comorbidity of osteoporosis and sarcopenia in the elderly, involves bone-muscle crosstalk, but its core molecular mechanism remains unclear. miR-206 is traditionally considered muscle-specific; this study explores miR-206-3p’s expression in musculoskeletal tissue and correlation with clinical parameters.

Methods

A prospective cohort of 158 elderly hip fracture patients (79 osteosarcopenia, 79 controls) was enrolled. qRT-PCR, in situ hybridization, and scRNA-seq were used to analyze miR-206-3p’s expression, distribution, and cell specificity. Correlations with grip strength, gait speed, and BMD were assessed.

Results

miR-206-3p was significantly downregulated in both tissues of the osteosarcopenia group (P < 0.001), highly expressed in Myod1⁺ muscle satellite cells and Runx2⁺ osteoprogenitor cells (> 82%), and weakly in mature cells (< 12%). It positively correlated with grip strength, gait speed, and BMD (r = 0.562–0.682, P < 0.001).

Conclusion

miR-206-3p is co-expressed in bone-muscle progenitor cells, with synchronous downregulation linked to functional decline, challenging its "muscle-specific" notion and serving as a key molecular hub for bone-muscle crosstalk.