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Background <p>Degenerative spondylolisthesis affects approximately 39&#xa0;million patients worldwide. While consensus supports decompression with fusion for single-level pathology, optimal surgical approaches for multi-level disease remain disputed. Despite the frequency of this clinical presentation, evidence comparing outcomes between Single-Level versus Multi-Level interbody fusion procedures is surprisingly scarce. This study aims to determine how the level of interbody fusion extent impacts outcomes in patients undergoing lumbar fusion for degenerative spondylolisthesis.</p> Methods <p>Our systematic review methodology involved comprehensive database searches (Web of Science, Scopus, PubMed, and Cochrane Library) from inception through April 2025. Two independent reviewers performed article screening, data extraction, and quality assessment. Statistical analyses used R software (v4.4.2), with outcomes reported as risk ratios for categorical variables and mean differences for continuous measures (95% CI). The certainty of evidence was assessed using the GRADE approach.</p> Results <p>Our meta-analysis evaluated 10 studies (<i>N</i> = 1430 patients; 971 Single-Level, 366 Double-Level, 198 Multi-Level fusions). Single-Level procedures demonstrated 41% lower revision rates (RR = 0.59 [0.40–0.86], <i>p</i> = 0.007). Operative advantages included reduced surgical time (−60.73&#xa0;min [− 80.89 to − 40.57], <i>p</i> &lt; 0.001), blood loss (-286.99mL [− 496.71 to − 77.27], <i>p</i> = 0.007), and hospitalization (−1.22 days [− 2.09 to − 0.34], <i>p</i> = 0.006). Oswestry Disability Index (ODI) scores showed borderline improvement (-3.90 [− 7.89 to 0.10], <i>p</i> = 0.06). Screw loosening decreased by 84% (RR = 0.16 [0.08–0.34], <i>p</i> &lt; 0.001). We observed no significant differences in lumbar lordosis (-0.01 [− 1.75 to 1.72], <i>p</i> = 0.99), infection rates (RR = 0.49 [0.19–1.25], <i>p</i> = 0.13), adjacent segment deterioration, vascular injuries, or dural tears. The certainty of evidence ranged from low to very low, and high heterogeneity was observed in perioperative outcomes.</p> Conclusions <p>Single-level fusion may offer a more favorable perioperative profile than double- or multi-level constructs, including lower revision risk, shorter operative time, reduced blood loss, shorter hospitalization, and fewer screw loosening events in pooled analyses. However, complications did not differ significantly between groups. Given substantial heterogeneity for perioperative outcomes and generally low to very low certainty of evidence, these findings should be interpreted cautiously and individualized to patient pathology and surgical context.</p>

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Single level versus multi-level lumbar interbody fusion for lumbar degenerative diseases: a systematic review and meta analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月14日

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  • Dana Ibrahim Alharbi,
  • Waleed Osama Samarkandi,
  • Leen Saleh Albraik,
  • Layan Saleh Albraik,
  • Muteb Nasser Alotaibi,
  • Nasser Ahmad Alsaleh,
  • Usman Salman Ali,
  • Yaser Ali Alnafesh,
  • Abdullah Hassan Latifah,
  • Abdulrahman Alnwiji,
  • Mohammed Omar Alamodi,
  • Raed A. Albar,
  • Ayman MA Mohamed

摘要

Background

Degenerative spondylolisthesis affects approximately 39 million patients worldwide. While consensus supports decompression with fusion for single-level pathology, optimal surgical approaches for multi-level disease remain disputed. Despite the frequency of this clinical presentation, evidence comparing outcomes between Single-Level versus Multi-Level interbody fusion procedures is surprisingly scarce. This study aims to determine how the level of interbody fusion extent impacts outcomes in patients undergoing lumbar fusion for degenerative spondylolisthesis.

Methods

Our systematic review methodology involved comprehensive database searches (Web of Science, Scopus, PubMed, and Cochrane Library) from inception through April 2025. Two independent reviewers performed article screening, data extraction, and quality assessment. Statistical analyses used R software (v4.4.2), with outcomes reported as risk ratios for categorical variables and mean differences for continuous measures (95% CI). The certainty of evidence was assessed using the GRADE approach.

Results

Our meta-analysis evaluated 10 studies (N = 1430 patients; 971 Single-Level, 366 Double-Level, 198 Multi-Level fusions). Single-Level procedures demonstrated 41% lower revision rates (RR = 0.59 [0.40–0.86], p = 0.007). Operative advantages included reduced surgical time (−60.73 min [− 80.89 to − 40.57], p < 0.001), blood loss (-286.99mL [− 496.71 to − 77.27], p = 0.007), and hospitalization (−1.22 days [− 2.09 to − 0.34], p = 0.006). Oswestry Disability Index (ODI) scores showed borderline improvement (-3.90 [− 7.89 to 0.10], p = 0.06). Screw loosening decreased by 84% (RR = 0.16 [0.08–0.34], p < 0.001). We observed no significant differences in lumbar lordosis (-0.01 [− 1.75 to 1.72], p = 0.99), infection rates (RR = 0.49 [0.19–1.25], p = 0.13), adjacent segment deterioration, vascular injuries, or dural tears. The certainty of evidence ranged from low to very low, and high heterogeneity was observed in perioperative outcomes.

Conclusions

Single-level fusion may offer a more favorable perioperative profile than double- or multi-level constructs, including lower revision risk, shorter operative time, reduced blood loss, shorter hospitalization, and fewer screw loosening events in pooled analyses. However, complications did not differ significantly between groups. Given substantial heterogeneity for perioperative outcomes and generally low to very low certainty of evidence, these findings should be interpreted cautiously and individualized to patient pathology and surgical context.